Macrophage biology in development, homeostasis and disease.
Macrophage biology in development, homeostasis and disease.
复制标题
作者：
巨噬细胞是造血系统中可塑性最强的细胞，存在于所有组织中，表现出极大的功能多样性。它们在发育、内稳态、组织修复和免疫方面都发挥着作用。虽然在解剖学上有所不同，组织驻留巨噬细胞呈现出不同的转录谱和功能能力，但它们对于维持内稳态都是必需的。然而，这些修复和内稳态功能可能会被慢性损伤破坏，导致巨噬细胞与疾病状态存在因果关联。在这篇综述中，我们讨论巨噬细胞如何调节正常生理和发育，并提供它们在疾病中的病理生理作用的几个例子。我们定义了执行特定功能的巨噬细胞的“特征”，同时考虑到对其谱系、特性和调控多样性的新见解。这种多样性至关重要，因为巨噬细胞已成为许多重要人类疾病的重要治疗靶点。
Macrophages the most plastic cells of the hematopoietic system are found in all tissues and exhibit great functional diversity. They have roles in development, homeostasis, tissue repair, and immunity. While anatomically distinct, resident tissue macrophages exhibit different transcriptional profiles, and functional capabilities, they are all required for the maintenance of homeostasis. However, these reparative and homeostatic functions can be subverted by chronic insults, resulting in a causal association of macrophages with disease states. In this review, we discuss how macrophages regulate normal physiology and development and provide several examples of their pathophysiologic roles in disease. We define the “hallmarks” of macrophages performing particular functions, taking into account novel insights into the diversity of their lineages, identity, and regulation. This diversity is essential to understand because macrophages have emerged as important therapeutic targets in many important human diseases.
登录
查看更多内容
影响因子：
7.2
作者：
Coussens, Lisa M.;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
20.3
作者：
Fantin, Alessandro;Vieira, Joaquim M.;Ruhrberg, Christiana
通讯作者：
Ruhrberg, Christiana
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C