Resting state EEG abnormalities in autism spectrum disorders.

Resting state EEG abnormalities in autism spectrum disorders.
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DOI:
10.1186/1866-1955-5-24
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发表时间:
2013-09-16
影响因子:
4.9
通讯作者:
Sweeney JA
Sweeney JA
中科院分区:
医学2区
文献类型:
--
作者:
Wang J;Barstein J;Ethridge LE;Mosconi MW;Takarae Y;Sweeney JA

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自闭症谱系障碍(ASD)是一组涉及多种神经系统功能障碍的复杂异质性发育障碍。在努力了解神经生理学底物,确定不同亚组的患者的病因病理生理学,并跟踪结果的新的治疗与翻译生物标志物,脑电图(脑电图)研究提供了一个有前途的研究策略,在ASD。ASD的静息状态EEG研究表明,电生理功率改变呈U形,低频和高频带功率过大,功能连接异常,左半球功率增强。在这篇综述中,我们提供了一个总结最近的研究结果,讨论了现有研究的局限性,可能会导致文献中的不一致,并为未来在这一领域的研究提出了建议,以促进对ASD的理解。
Autism spectrum disorders (ASD) are a group of complex and heterogeneous developmental disorders involving multiple neural system dysfunctions. In an effort to understand neurophysiological substrates, identify etiopathophysiologically distinct subgroups of patients, and track outcomes of novel treatments with translational biomarkers, EEG (electroencephalography) studies offer a promising research strategy in ASD. Resting-state EEG studies of ASD suggest a U-shaped profile of electrophysiological power alterations, with excessive power in low-frequency and high-frequency bands, abnormal functional connectivity, and enhanced power in the left hemisphere of the brain. In this review, we provide a summary of recent findings, discuss limitations in available research that may contribute to inconsistencies in the literature, and offer suggestions for future research in this area for advancing the understanding of ASD.
DOI: 10.1212/wnl.58.3.428
发表时间: 2002-02-12
期刊: NEUROLOGY
影响因子: 9.9
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