The changing face of pathogen discovery and surveillance.
The changing face of pathogen discovery and surveillance.
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DOI：
10.1038/nrmicro2949
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发表时间：
2013-02
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影响因子：
--
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随着贸易和旅行的全球化、农业实践的变化和气候变化，新的微生物感染的出现越来越有可能。然而，正如Lipkin在这篇文章中所描述的那样，这种威胁正在通过病原体发现，监测和建模方面的巨大技术进步来应对。病原体发现的步伐正在迅速加快。这不仅反映了导致新的微生物感染出现和全球化的因素，也反映了确定新疾病病因的方法的改进。创新的分子诊断平台、对病原体监测（野生动物、家畜和人类）的投资以及社交媒体工具的出现（这些工具可以在万维网上挖掘表明传染病爆发发生的线索），都被证明对早期识别公共卫生威胁非常宝贵。此外，微生物发病机制的模型正变得越来越复杂，为微生物导致癌症、消化性溃疡和精神疾病等慢性疾病的机制提供了新的见解。在这里，我回顾了导致传染病出现的因素，以及应对病原体监测和发现挑战的策略。
The emergence of new microbial infections is ever more likely with the globalization of trade and travel, changes to agricultural practices and climate change. However, as Lipkin describes in this Essay, this threat is being met by dramatic technological advances in pathogen discovery, surveillance and modelling. The pace of pathogen discovery is rapidly accelerating. This reflects not only factors that enable the appearance and globalization of new microbial infections, but also improvements in methods for ascertaining the cause of a new disease. Innovative molecular diagnostic platforms, investments in pathogen surveillance (in wildlife, domestic animals and humans) and the advent of social media tools that mine the World Wide Web for clues indicating the occurrence of infectious-disease outbreaks are all proving to be invaluable for the early recognition of threats to public health. In addition, models of microbial pathogenesis are becoming more complex, providing insights into the mechanisms by which microorganisms can contribute to chronic illnesses like cancer, peptic ulcer disease and mental illness. Here, I review the factors that contribute to infectious-disease emergence, as well as strategies for addressing the challenges of pathogen surveillance and discovery.
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DOI：
10.1073/pnas.0335853100
发表时间：
2003-02-04
影响因子：
11.1
作者：
Brüggemann, H;Bäumer, S;Gottschalk, G
通讯作者：
Gottschalk, G
影响因子：
10.7
作者：
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通讯作者：
Pybus, Oliver G.
DOI：
10.1073/pnas.89.23.11486
发表时间：
1992-12-01
影响因子：
11.1
作者：
BRIESE, T;DELATORRE, JC;LIPKIN, WI
通讯作者：
LIPKIN, WI
影响因子：
17.1
作者：
Blumberg R;Powrie F
通讯作者：
Powrie F
影响因子：
64.8
作者：
Claesson, Marcus J.;Jeffery, Ian B.;O'Toole, Paul W.
通讯作者：
O'Toole, Paul W.