Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study.
Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study.
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γ-谷氨酰转移酶与高尿酸血症之间的横断面关联：中国多种族队列（CMEC）研究
DOI：
10.1136/bmjopen-2021-058793
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发表时间：
2022-05-30
期刊：
影响因子：
2.9
通讯作者：
Yin, Jianzhong
中科院分区：
文献类型：
--
作者：
Wang, Yanjiao;Xu, Fang;Zhang, Xuehui;Mi, Fei;Qian, Ying;Hong, Rudan;Zou, Wei;Bai, Hua;He, Likun;Wang, Songmei;Yin, Jianzhong
一些研究表明γ -谷氨酰转移酶（GGT）与高尿酸血症之间存在关联，但在欠发达的少数民族地区对这种关系知之甚少。我们横断面分析了来自中国多民族队列（云南地区）的数据。横断面研究。22 020名参与者，年龄在30-79岁之间，来自汉族、彝族和白族。测定血清尿酸、GGT等代谢指标。测量了体重、身高和血压。吸烟、饮酒、种族、教育程度和病史都是通过问卷调查获得的。在粗模型中，与最低五分位数相比，血清GGT的第二、第三、第四和第五五分位数与高尿酸血症风险呈正相关（OR=1.69、2.90、4.34和7.70,95% CI分别为1.42 ~ 2.01、2.47 ~ 3.42、3.71 ~ 5.09和6.60 ~ 8.98，p趋势<0.0001）。在完全调整模型中，与最低五分位数相比，血清GGT的第二、第三、第四和第五五分位数也与高尿酸血症风险呈正相关（OR=1.26、1.68、2.02和3.02,95% CI分别为1.04 ~ 1.51、1.40 ~ 2.00、1.69 ~ 2.42和2.51 ~ 3.64，p趋势<0.0001）。各民族分别进行Logistic回归模型分析。与第一五分位数相比，三个民族GGT水平最高与高尿酸血症的高风险相关(OR （95% CI)：汉族、彝族和白族分别为2.89（2.26 ~ 3.68）、2.81（1.93 ~ 4.11）和3.04 (1.91 ~ 4.84)，p趋势<0.0001）。GGT与高尿酸血症的关系也在不同年龄组和性别组中进行了观察。在中国欠发达少数民族地区，高血清GGT水平与高尿酸血症的高风险相关。
Several studies have demonstrated the association between gamma-glutamyl transferase (GGT) and hyperuricaemia, but little is known about such relation in less-developed ethnic minority regions. We cross-sectionally analysed data from the China Multi-Ethnic Cohort (Yunnan region). Cross-sectional study. 22 020 participants aged 30–79 years from Han ethnicity, Yi ethnicity and Bai ethnicity. The serum level of uric acid, GGT and other metabolic parameters were tested. Weight, height and blood pressure were measured. Smoking, drinking, ethnicity, education and medical history were obtained from questionnaires. In the crude model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT exhibited a positive association with hyperuricaemia risk (OR=1.69, 2.90, 4.34 and 7.70, 95% CI=1.42 to 2.01, 2.47 to 3.42, 3.71 to 5.09 and 6.60 to 8.98, respectively, p-trend<0.0001). In fully adjusted model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT also exhibited a positive association with hyperuricaemia risk (OR=1.26, 1.68, 2.02 and 3.02, 95% CI=1.04 to 1.51, 1.40 to 2.00, 1.69 to 2.42 and 2.51 to 3.64, respectively, p-trend<0.0001). Logistic regression model was conducted separately in ethnic groups. Compared with first quintile, the highest GGT level were related to higher risk of hyperuricaemia in three ethnic groups (OR (95% CI): 2.89 (2.26 to 3.68), 2.81 (1.93 to 4.11) and 3.04 (1.91 to 4.84) for Han, Yi and Bai ethnicity, respectively, p-trend <0.0001). The relationship between GGT and hyperuricaemia was also observed in different age groups or gender groups. High serum GGT level was related to a higher risk of hyperuricaemia in less-developed ethnic minority regions in China.
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DOI：
10.1177/03000605211028140
发表时间：
2021-07
期刊：
The Journal of international medical research
影响因子：
--
作者：
Gao C;Chen Z;Ma J;Xie J;Zhang W;Ren H;Chen X
通讯作者：
Chen X
影响因子：
4.5
作者：
Cox CL;Stanhope KL;Schwarz JM;Graham JL;Hatcher B;Griffen SC;Bremer AA;Berglund L;McGahan JP;Keim NL;Havel PJ
通讯作者：
Havel PJ
影响因子：
4.7
作者：
Nanri H;Hara M;Nishida Y;Shimanoe C;Nakamura K;Higaki Y;Imaizumi T;Taguchi N;Sakamoto T;Horita M;Shinchi K;Kokaze A;Tanaka K
通讯作者：
Tanaka K
影响因子：
3.9
作者：
Maloberti A;Biolcati M;Ruzzenenti G;Giani V;Leidi F;Monticelli M;Algeri M;Scarpellini S;Nava S;Soriano F;Oreglia J;Sacco A;Morici N;Oliva F;Piani F;Borghi C;Giannattasio C
通讯作者：
Giannattasio C
DOI：
10.1002/art.22762
发表时间：
2007-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Choi, Hyon K.;Curhan, Gary
通讯作者：
Curhan, Gary