The Role of Uric Acid in Acute and Chronic Coronary Syndromes.
The Role of Uric Acid in Acute and Chronic Coronary Syndromes.
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DOI：
10.3390/jcm10204750
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发表时间：
2021-10-16
影响因子：
3.9
通讯作者：
Giannattasio C
中科院分区：
文献类型：
--
作者：
Maloberti A;Biolcati M;Ruzzenenti G;Giani V;Leidi F;Monticelli M;Algeri M;Scarpellini S;Nava S;Soriano F;Oreglia J;Sacco A;Morici N;Oliva F;Piani F;Borghi C;Giannattasio C
尿酸（UA）是内源性和外源性嘌呤核苷酸代谢的终产物。虽然它与关节痛风和肾脏疾病的关系已经知道了很长一段时间，新的数据表明，UA也与心血管（CV）疾病有关。UA已被确定为许多不同结局的重要决定因素，例如全因死亡率和CV死亡率，以及CV事件（主要是急性冠状动脉综合征（ACS）甚至卒中）。此外，UA与心力衰竭的发展、失代偿患者的较高死亡率以及心房颤动的发作有关。在简要介绍UA在心血管疾病中的一般作用后，本文将重点介绍UA与心血管结局的关系，以及ACS和慢性冠状动脉综合征患者的具体特征。最后，将讨论两个尚未解决的问题：第一个问题是关于CV UA临界值的确定，而第二个问题是关于药物降低UA能够降低CV事件发生率的可能性。
Uric acid (UA) is the final product of the catabolism of endogenous and exogenous purine nucleotides. While its association with articular gout and kidney disease has been known for a long time, new data have demonstrated that UA is also related to cardiovascular (CV) diseases. UA has been identified as a significant determinant of many different outcomes, such as all-cause and CV mortality, and also of CV events (mainly Acute Coronary Syndromes (ACS) and even strokes). Furthermore, UA has been related to the development of Heart Failure, and to a higher mortality in decompensated patients, as well as to the onset of atrial fibrillation. After a brief introduction on the general role of UA in CV disorders, this review will be focused on UA’s relationship with CV outcomes, as well as on the specific features of patients with ACS and Chronic Coronary Syndrome. Finally, two issues which remain open will be discussed: the first is about the identification of a CV UA cut-off value, while the second concerns the possibility that the pharmacological reduction of UA is able to lower the incidence of CV events.
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