Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish.

Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish.
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DOI:
10.1002/mrd.21128
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发表时间:
2010-04
影响因子:
2.5
通讯作者:
Pelegri, Francisco
Pelegri, Francisco
中科院分区:
生物学3区
文献类型:
--
作者:
Lindeman, Robin E.;Pelegri, Francisco

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在合子转录开始之前的动物发育的最早阶段,所有关键的细胞过程都是由卵子发生期间积累在卵子中的母体提供的分子产物进行的。这些母体产物的破坏可导致有缺陷的胚胎发生。在这篇综述中,我们专注于母系基因的作用,受精,细胞分裂,中心体调节和生殖细胞发育的基本过程中,重点从斑马鱼的研究结果,因为这是一个独特的和有价值的模型系统的脊椎动物生殖。摩尔Reprod. Dev. 77:299-313,2010.© 2009 Wiley利斯公司
In the earliest stages of animal development prior to the commencement of zygotic transcription, all critical cellular processes are carried out by maternally‐provided molecular products accumulated in the egg during oogenesis. Disruption of these maternal products can lead to defective embryogenesis. In this review, we focus on maternal genes with roles in the fundamental processes of fertilization, cell division, centrosome regulation, and germ cell development with emphasis on findings from the zebrafish, as this is a unique and valuable model system for vertebrate reproduction. Mol. Reprod. Dev. 77: 299–313, 2010. © 2009 Wiley‐Liss, Inc.
DOI: 10.1006/dbio.1997.8815
发表时间: 1998-02-01
影响因子: 2.7
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