Role of Serotonin Transporter Polymorphisms in the Behavioural and Psychological Symptoms in Probable Alzheimer Disease Patients
Role of Serotonin Transporter Polymorphisms in the Behavioural and Psychological Symptoms in Probable Alzheimer Disease Patients
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血清素转运蛋白多态性在可能的阿尔茨海默病患者行为和心理症状中的作用
DOI：
10.1159/000107081
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发表时间：
2007
影响因子：
2.4
通讯作者：
C. Lendon
中科院分区：
文献类型：
--
作者：
A. Pritchard;Colin W. Pritchard;P. Bentham;C. Lendon
背景/目的：阿尔茨海默病(AD)患者通常患有痴呆的行为和心理症状(BPSD)。阿尔茨海默病的发生与BPSD的遗传因素有关。这是一项关于5-羟色胺转运体(SERT)的连锁多态区域和可变数目串联重复变异是否与BPSD相关的研究。方法：采用神经精神病学问卷对367例AD患者进行BPSD的纵向测量。有良好证据表明5-羟色胺能参与的措施(妄想、幻觉、抑郁、焦虑、激动/攻击和易怒)与连锁多态区域和可变数目串联重复变异的基因和等位基因频率有关。结果：连锁多态区变异长等位基因与易怒和可变数目串联重复序列10重复等位基因与精神疾病显著相关，但与抑郁、焦虑、激越/攻击行为无关。结论：我们的数据和对以前研究的回顾表明，SERT在精神病和攻击性/易怒倾向的发展中可能起到很小的作用；然而，需要在大规模的、特征良好的队列中进行进一步的研究。
Background/Aims: Alzheimer disease (AD) patients commonly suffer from behavioural and psychological symptoms of dementia (BPSD). A genetic component to BPSD development in AD has been demonstrated. This is an investigation of whether the linked polymorphic region and variable number tandem repeat variants of the serotonin transporter (SERT) are associated with BPSD. Methods: The longitudinal measures of BPSD of our large cohort of 367 AD patients were assessed by the Neuropsychiatric Inventory. Measures with good evidence of serotonergic involvement (delusions, hallucinations, depression, anxiety, agitation/aggression and irritability) were related to genotype and allele frequencies of the linked polymorphic region and variable number tandem repeat variants. Results: Analysis revealed significant relationships between the linked polymorphic region variant long allele with irritability and the variable number tandem repeat 10-repeat allele with psychosis, but no associations were found with depression, anxiety or agitation/aggression. Conclusion: Our data and review of previous studies suggest SERT could play a minor role in development of psychosis and aggressive/irritable tendencies; however, further investigations are required in large, well-characterized cohorts.
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影响因子：
--
作者：
Danielle L. Sukonick;B. Pollock;R. Sweet;B. Mulsant;J. Rosen;W. Klunk;K. Kastango;S. DeKosky;R. Ferrell
通讯作者：
Danielle L. Sukonick;B. Pollock;R. Sweet;B. Mulsant;J. Rosen;W. Klunk;K. Kastango;S. DeKosky;R. Ferrell
使用 [123I]beta-CIT SPECT 测量与血清素转运蛋白基因型相关的中枢血清素转运蛋白可用性。
DOI：
10.1176/appi.ajp.161.3.525
发表时间：
2004
期刊：
The American journal of psychiatry
影响因子：
--
作者：
vanDyck,ChristopherH;Malison,RobertT;Staley,JulieK;Jacobsen,LeslieK;Seibyl,JohnP;Laruelle,Marc;Baldwin,RonaldM;Innis,RobertB;Gelernter,Joel
通讯作者：
Gelernter,Joel
证实情感障碍家族史与阿尔茨海默氏病抑郁综合征之间的关联。
DOI：
10.1176/ajp.153.10.1340
发表时间：
1996
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Strauss,ME;Ogrocki,PK
通讯作者：
Ogrocki,PK
情感障碍家族史与阿尔茨海默病抑郁综合征之间的关联。
DOI：
10.1176/ajp.147.4.452
发表时间：
1990
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Pearlson,GD;Ross,CA;Lohr,WD;Rovner,BW;Chase,GA;Folstein,MF
通讯作者：
Folstein,MF