Maternal and Cord Blood Serum Metabolite Associations with Childhood Adiposity and Body Composition Outcomes.
Maternal and Cord Blood Serum Metabolite Associations with Childhood Adiposity and Body Composition Outcomes.
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DOI：
10.3390/metabo13060749
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发表时间：
2023-06-13
期刊：
影响因子：
4.1
通讯作者：
Lowe Jr, William L. L.
中科院分区：
文献类型：
--
作者：
Bianco, Monica E. E.;Vu, My H. H.;Bain, James R. R.;Muehlbauer, Michael J. J.;Ilkayeva, Olga R. R.;Scholtens, Denise M. M.;Josefson, Jami;Lowe Jr, William L. L.
关键词：
母体代谢物对新生儿大小的影响独立于母体体重指数（BMI）和血糖，突出了母体代谢对后代结局的重要性。本研究利用来自高血糖和不良妊娠结局（HAPO）研究和HAPO随访研究的表型和代谢组学数据，研究了妊娠期间母体代谢物与儿童肥胖的关系，以及脐带血代谢物与儿童肥胖的关系。母体代谢物分析包括2324对母婴，脐带血代谢物分析包括937对后代。采用多元逻辑回归和线性回归来检验主要预测因子、母体或脐带血代谢物与儿童肥胖结局之间的关联。在模型1中，母亲多次禁食和1小时代谢物与儿童肥胖结局显著相关，但在调整母亲BMI和/或母亲血糖后不再显著。在完全调整模型中，空腹乳糖水平与儿童BMI z分数和腰围呈负相关，而空腹尿素水平与腰围呈正相关。1小时蛋氨酸与无脂质量呈正相关。脐带血代谢物与儿童肥胖结局之间没有显著关联。在调整母体BMI和葡萄糖后，很少有代谢物与儿童肥胖结局相关，这表明母体BMI可以解释母体代谢物与儿童肥胖之间的关联。
Maternal metabolites influence the size of newborns independently of maternal body mass index (BMI) and glycemia, highlighting the importance of maternal metabolism on offspring outcomes. This study examined associations of maternal metabolites during pregnancy with childhood adiposity, and cord blood metabolites with childhood adiposity using phenotype and metabolomic data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and the HAPO Follow-Up Study. The maternal metabolites analyses included 2324 mother–offspring pairs, while the cord blood metabolites analyses included 937 offspring. Multiple logistic and linear regression were used to examine associations between primary predictors, maternal or cord blood metabolites, and childhood adiposity outcomes. Multiple maternal fasting and 1 hr metabolites were significantly associated with childhood adiposity outcomes in Model 1 but were no longer significant after adjusting for maternal BMI and/or maternal glycemia. In the fully adjusted model, fasting lactose levels were negatively associated with child BMI z-scores and waist circumference, while fasting urea levels were positively associated with waist circumference. One-hour methionine was positively associated with fat-free mass. There were no significant associations between cord blood metabolites and childhood adiposity outcomes. Few metabolites were associated with childhood adiposity outcomes after adjusting for maternal BMI and glucose, suggesting that maternal BMI accounts for the association between maternal metabolites and childhood adiposity.
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影响因子：
9.8
作者：
Catalano PM;Hauguel-De Mouzon S
通讯作者：
Hauguel-De Mouzon S
影响因子：
8.2
作者：
Kadakia, Rachel;Nodzenski, Michael;Lowe, William L., Jr.
通讯作者：
Lowe, William L., Jr.
影响因子：
4.1
作者：
Gleason B;Kuang A;Bain JR;Muehlbauer MJ;Ilkayeva OR;Scholtens DM;Lowe WL Jr
通讯作者：
Lowe WL Jr
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.6
作者：
Neville, MC;Morton, J;Umemura, S
通讯作者：
Umemura, S