Is obesity an oral bacterial disease?
Is obesity an oral bacterial disease?
复制标题
DOI：
10.1177/0022034509338353
复制
发表时间：
2009-06
影响因子：
7.6
通讯作者：
Carpino E
中科院分区：
文献类型：
--
作者：
Goodson JM;Groppo D;Halem S;Carpino E
全球范围内超重人口的爆炸性增长被称为流行病。肥胖症的炎症性已被广泛认识。这真的会是一种涉及传染病的流行病吗？在这种对社会中日益普遍的超重状况感到担忧的气氛中，我们关注口腔细菌作为潜在的直接致肥者的可能作用。为了研究这种可能性，我们测量了超重女性的唾液细菌数量。采集了313名女性的唾液，这些女性的体重指数在27到32之间，通过DNA探针分析测量了细菌数量。这一组的水平与牙周病研究中作为健康正常受试者的232人的数据进行了比较。在测量的40种细菌中，有7种在超重女性的唾液中的中位数百分比差异超过2%。唾液微生物组成的分类树分析表明，98.4%的超重妇女可以通过单一细菌种类(新色单胞菌)的存在超过唾液细菌总数的1.05%来识别。这些数据表明，超重女性的唾液细菌组成发生了变化。这些细菌似乎很可能是正在发展的超重状况的生物学指标。更令人感兴趣的是，未来研究的主题是口腔细菌，如诺氧链球菌，可能参与导致肥胖的病理。
The world-wide explosion of overweight people has been called an epidemic. The inflammatory nature of obesity is widely recognized. Could it really be an epidemic involving an infectious agent? In this climate of concern over the increasing prevalence of overweight conditions in our society, we focus on the possible role of oral bacteria as a potential direct contributor to obesity. In order to investigate this possibility we measured salivary bacterial populations of overweight women. Saliva was collected from 313 women with a body mass index between 27 and 32 and bacterial populations measured by DNA probe analysis. Levels in this group were compared with data from a population of 232 subjects that served as healthy normal subjects in periodontal disease studies. The median percentage difference of 7 of the 40 bacterial species measured was greater than 2% in the saliva of overweight women. Classification tree analysis of salivary microbiological composition revealed that 98.4% of the overweight women could be identified by the presence of a single bacterial species (Selenomonas noxia) at levels greater than 1.05% of the total salivary bacteria. These data suggest the composition of salivary bacteria change in overweight women. It seems likely that these bacterial species could serve as biological indicators of a developing overweight condition. Of even greater interest and the subject of future research is the possibility that oral bacteria, such as S. noxia, may participate in the pathology that leads to obesity.
登录
查看更多内容
影响因子：
6.7
作者：
Tanner, A;Maiden, MFJ;Kent, RL
通讯作者：
Kent, RL
影响因子：
158.5
作者：
Christakis, Nicholas A.;Fowler, James H.
通讯作者：
Fowler, James H.
影响因子：
--
作者：
Socransky, SS;Haffajee, AD;Goodson, JM
通讯作者：
Goodson, JM
影响因子：
8.9
作者：
DiBaise, John K.;Zhang, Husen;Rittmann, Bruce E.
通讯作者：
Rittmann, Bruce E.
影响因子：
6.7
作者：
Buduneli, N;Baylas, H;Dahlen, G
通讯作者：
Dahlen, G