Associations between endogenous sex hormone levels and adipokine levels in the Multi-Ethnic Study of Atherosclerosis.
Associations between endogenous sex hormone levels and adipokine levels in the Multi-Ethnic Study of Atherosclerosis.
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在动脉粥样硬化的多种族研究中，内源性激素水平与脂肪因子水平之间的关联。
DOI：
10.3389/fcvm.2022.1062460
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发表时间：
2022
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
--
作者：
性激素水平的差异导致心血管疾病（CVD）风险的差异。脂肪因子在心脏代谢途径中发挥作用，并与CVD有不同的关联。脂肪因子水平因性别而异;然而，性激素谱和脂肪因子之间的关联还没有很好地建立。我们假设绝经后女性的性激素水平与瘦素和脂联素水平的升高有关，而男性的性激素水平与此相反。我们对动脉粥样硬化多种族研究中的1，811名成年人进行了分析，他们的性激素和脂肪因子测量平均间隔2.6年。在检查1时测量性激素[睾酮（T）、雌二醇（E2）、性激素结合球蛋白（SHBG）和脱氢表雄酮（DHEA）];估计游离T。在第2次或第3次检查时测量血清脂肪因子（瘦素、瘦素、脂联素）。我们使用多变量线性回归来研究性激素和脂肪因子之间的横截面关联。平均（SD）年龄为63（10）岁，48%为女性; 59%为非白人参与者。对于瘦素，仅调整人口统计学后，女性中较高的游离T和较低的SHBG与较高的瘦素相关;这种相关性在进一步协变量调整后减弱。然而，在男性中，在完全校正的模型中，较高的游离T和较低的SHBG与较高的瘦素水平相关。对于脂联素，在调整CVD危险因素后，女性和男性中较低的游离T和较高的SHBG与较高的脂联素相关。在女性中，没有发现与总T和bioT的显著相关性，但在男性中观察到与总T和毕奥的负相关性。总的来说，这些结果进一步表明，更多的雄激素性特征（较高的游离T和较低的SHBG）与不太有利的脂肪因子模式相关。这些发现可能为性激素、脂肪因子和心血管疾病风险之间的相互作用提供机制性的见解。
Differences in sex hormone levels contribute to differences in cardiovascular disease (CVD) risk. Adipokines play a role in cardiometabolic pathways and have differing associations with CVD. Adipokine levels differ by sex; however, the association between sex hormone profiles and adipokines is not well established. We hypothesized that a more androgenic sex hormone profile would be associated with higher leptin and resistin and lower adiponectin levels among postmenopausal women, with the opposite associations in men. We performed an analysis of 1,811 adults in the Multi-Ethnic Study of Atherosclerosis who had both sex hormones and adipokines measured an average of 2.6 years apart. Sex hormones [Testosterone (T), estradiol (E2), sex hormone binding globulin (SHBG), and dehydroepiandrosterone (DHEA)] were measured at exam 1; free T was estimated. Serum adipokines (leptin, resistin, adiponectin) were measured at exams 2 or 3. We used multivariable linear regression to examine the cross-sectional associations between sex hormones and adipokines. The mean (SD) age was 63 (10) years, 48% were women; 59% non-White participants. For leptin, after adjusting for demographics only, higher free T and lower SHBG, were associated with higher leptin in women; this association was attenuated after further covariate adjustment. However in men, higher free T and lower SHBG were associated with greater leptin levels in fully adjusted models. For adiponectin, lower free T and higher SHBG were associated with greater adiponectin in both women and men after adjustment for CVD risk factors. For resistin, no significant association was found women, but an inverse association with total T and bioT was seen in men. Overall, these results further suggest a more androgenic sex profile (higher free T and lower SHBG) is associated with a less favorable adipokine pattern. These findings may provide mechanistic insight into the interplay between sex hormones, adipokines, and CVD risk.
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影响因子：
5.8
作者：
Mongraw-Chaffin, Morgana L.;Anderson, Cheryl A. M.;Golden, Sherita Hill
通讯作者：
Golden, Sherita Hill
影响因子：
11.1
作者：
Hellström, L;Wahrenberg, H;Arner, P
通讯作者：
Arner, P
影响因子：
4.1
作者：
Chu, Jian H;Michos, Erin D;Ouyang, Pamela;Vaidya, Dhananjay;Blumenthal, Roger S;Budoff, Matthew J;Blaha, Michael J;Whelton, Seamus P
通讯作者：
Whelton, Seamus P
影响因子：
5.4
作者：
Gassett AJ;Sheppard L;McClelland RL;Olives C;Kronmal R;Blaha MJ;Budoff M;Kaufman JD
通讯作者：
Kaufman JD
影响因子：
5.3
作者：
Martin, Seth S.;Blaha, Michael J.;Allison, Matthew A.
通讯作者：
Allison, Matthew A.