The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock.
The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock.
复制标题
DOI：
10.1016/j.cell.2021.07.001
复制
发表时间：
2021-08-05
期刊：
影响因子：
64.5
通讯作者：
Hooper LV
中科院分区：
文献类型：
--
作者：
Brooks JF 2nd;Behrendt CL;Ruhn KA;Lee S;Raj P;Takahashi JS;Hooper LV
环境光周期诱导动物的昼夜摄食行为，从而产生暴露于食源性细菌的节律。在这里，我们表明肠道微生物群在先天免疫中产生昼夜节律，与摄食节律同步，以预测微生物暴露。抗菌蛋白的节律性表达是由小鼠肠道微生物群成员分节丝状菌（SFB）在上皮附着中的每日节律驱动的。节律性SFB附着是由昼夜节律钟通过控制摄食节律来驱动的。从机制上讲，有节奏的SFB附着激活了涉及第3组先天淋巴细胞的免疫回路。该回路触发了上皮细胞STAT3表达和激活的振荡，产生了有节奏的抗菌蛋白表达，并导致对鼠伤寒沙门氏菌感染的抗性在昼夜周期中变化。因此，宿主进食节律与微生物群同步，以促进预期外源性微生物暴露的肠道先天免疫的节律。
Environmental light cycles entrain circadian feeding behaviors in animals that produce rhythms in exposure to foodborne bacteria. Here, we show that the intestinal microbiota generates diurnal rhythms in innate immunity that synchronize with feeding rhythms to anticipate microbial exposure. Rhythmic expression of antimicrobial proteins was driven by daily rhythms in epithelial attachment by segmented filamentous bacteria (SFB), members of the mouse intestinal microbiota. Rhythmic SFB attachment was driven by the circadian clock through control of feeding rhythms. Mechanistically, rhythmic SFB attachment activated an immunological circuit involving group 3 innate lymphoid cells. This circuit triggered oscillations in epithelial STAT3 expression and activation that produced rhythmic antimicrobial protein expression and caused resistance to Salmonella Typhimurium infection to vary across the day-night cycle. Thus, host feeding rhythms synchronize with the microbiota to promote rhythms in intestinal innate immunity that anticipate exogenous microbial exposure.
登录
查看更多内容
影响因子：
32.4
作者：
Hou B;Saudan P;Ott G;Wheeler ML;Ji M;Kuzmich L;Lee LM;Coffman RL;Bachmann MF;DeFranco AL
通讯作者：
DeFranco AL
影响因子：
30.3
作者：
Leone V;Gibbons SM;Martinez K;Hutchison AL;Huang EY;Cham CM;Pierre JF;Heneghan AF;Nadimpalli A;Hubert N;Zale E;Wang Y;Huang Y;Theriault B;Dinner AR;Musch MW;Kudsk KA;Prendergast BJ;Gilbert JA;Chang EB
通讯作者：
Chang EB
影响因子：
13.9
作者：
Mohawk JA;Green CB;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
56.9
作者：
Ley, Ruth E.;Hamady, Micah;Gordon, Jeffrey I.
通讯作者：
Gordon, Jeffrey I.
影响因子：
4.8
作者：
Madison, BB;Dunbar, L;Gumucio, DL
通讯作者：
Gumucio, DL