The Impact of 10% α-Hydroxy Acid Emulsion on Skin pH
The Impact of 10% α-Hydroxy Acid Emulsion on Skin pH
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%20Impact%20of%2010%%20α-羟基%20酸%20乳液%20on%20Skin%20pH
DOI：
10.1159/000331204
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发表时间：
2012
影响因子：
2.7
通讯作者：
Babilas P
中科院分区：
文献类型：
--
作者：
Schreml S;Meier RJ;Albert MG;Seidl U;Zeller V;Behm B;Landthaler M;Abels C;Babilas P
方法：将10% α-羟基酸（AHA）油/水（O/W）乳剂涂于12名男性志愿者前臂掌侧，10 min后擦去，测定涂药前和涂药后3 h内皮肤表面pH值（pHss）和角质层pH值（SC; pHsc）。我们使用玻璃电极测量和时域双寿命参考（tdDLR）与发光传感器箔。在另一个实验（n = 5）中，通过在施用AHA O/W乳剂后胶带剥离前臂掌侧的SC来测量AHA O/W乳剂对pHsc梯度的影响。（电极）]后10 min pH值显著降低[4.0 ± 0.3（tdDLR）或4.1 ± 0.1（电极）]和pH值在3小时的测量期间内保持显著降低[3小时后：4.4 ± 0.2（tdDLR）或4.5 ± 0.3（电极）]。AHA O/W乳剂显著降低了SC深层的pH值。结论：10%AHA O/W乳剂施用10 min后，可降低SC深层的pH值（至少3 h）和pH值。
Background/Aims:The effects of a 10% α-hydroxy acid (AHA) oil/water (O/W) emulsion on the pH of human skin surface (pHss) and stratum corneum (SC; pHsc) were evaluated in vivo.Methods:The AHA O/W emulsion was applied to an area on the volar forearm of male volunteers (n = 12), and then wiped off after 10 min. Prior to application and over the following 3 h, the pHsswas measured. We used glass electrode measurements and time domain dual lifetime referencing (tdDLR) with luminescent sensor foils. In another experiment (n = 5), the impact of the AHA O/W emulsion on the pHscgradient was measured by tape stripping of the SC of the volar forearm after application of the AHA O/W emulsion.Results:Compared with pHssvalues prior to treatment [5.2 ± 1.7 (tdDLR) or 4.8 ± 0.5 (electrode)], the pHsswas significantly reduced 10 min after application [4.0 ± 0.3 (tdDLR) or 4.1 ± 0.1 (electrode)] and the pHssremained significantly reduced over the measurement period of 3 h [after 3 h: 4.4 ± 0.2 (tdDLR) or 4.5 ± 0.3 (electrode)]. The AHA O/W emulsion significantly reduced the pHsceven down to deep layers of the SC.Conclusion:After a 10-min application time, the 10% AHA O/W emulsion reduces the pHss(for at least 3 h) and pHscin deep layers of the SC.
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影响因子：
3
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
1983
期刊：
Journal of General Microbiology
影响因子：
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作者：
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通讯作者：
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