Kappe neurons, a novel population of olfactory sensory neurons.
Kappe neurons, a novel population of olfactory sensory neurons.
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DOI：
10.1038/srep04037
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发表时间：
2014-02-10
影响因子：
4.6
通讯作者：
Korsching SI
中科院分区：
文献类型：
--
作者：
Ahuja G;Bozorg Nia S;Zapilko V;Shiriagin V;Kowatschew D;Oka Y;Korsching SI
嗅觉刺激的感知是由不同的嗅觉感觉神经元群体介导的，每个嗅觉感觉神经元都有一组特征的形态和功能参数。在硬骨鱼和软骨鱼中，除了两大类纤毛神经元和微绒毛神经元外，还发现了第三大类隐窝神经元。我们在这里报告了斑马鱼中一个新的第四嗅觉感觉神经元种群，我们将其命名为kappe神经元，因为它们的特征形状。Kappe神经元具有go样免疫反应性，在嗅上皮内具有明显的空间分布，与隐窝神经元相似，但又有显著差异。此外，kappe神经元投射到嗅球内的单一目标肾小球，即中嗅束mdg5，而隐窝神经元只投射到mdg2肾小球。Kappe神经元对已建立的纤毛、微绒毛和隐窝神经元标记物是阴性的，但似乎有微绒毛。Kappe神经元是硬骨鱼中第四种类型的嗅觉感觉神经元，它们的存在表明，嗅觉刺激的编码可能比周围嗅觉系统中迄今为止所假设的要复杂得多。
Perception of olfactory stimuli is mediated by distinct populations of olfactory sensory neurons, each with a characteristic set of morphological as well as functional parameters. Beyond two large populations of ciliated and microvillous neurons, a third population, crypt neurons, has been identified in teleost and cartilaginous fishes. We report here a novel, fourth olfactory sensory neuron population in zebrafish, which we named kappe neurons for their characteristic shape. Kappe neurons are identified by their Go-like immunoreactivity, and show a distinct spatial distribution within the olfactory epithelium, similar to, but significantly different from that of crypt neurons. Furthermore, kappe neurons project to a single identified target glomerulus within the olfactory bulb, mdg5 of the mediodorsal cluster, whereas crypt neurons are known to project exclusively to the mdg2 glomerulus. Kappe neurons are negative for established markers of ciliated, microvillous and crypt neurons, but appear to have microvilli. Kappe neurons constitute the fourth type of olfactory sensory neurons reported in teleost fishes and their existence suggests that encoding of olfactory stimuli may require a higher complexity than hitherto assumed already in the peripheral olfactory system.
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影响因子：
4.6
作者：
Ahuja, Gaurav;Ivandic, Ivan;Saltuerk, Mehmet;Oka, Yuichiro;Nadler, Walter;Korsching, Sigrun I.
通讯作者：
Korsching, Sigrun I.
DOI：
10.1073/pnas.1206724109
发表时间：
2012-08-14
影响因子：
11.1
作者：
Johnson, Mark A.;Tsai, Lulu;Barnea, Gilad
通讯作者：
Barnea, Gilad
影响因子：
5.3
作者：
DeMaria, Shannon;Berke, Allison P.;Ngai, John
通讯作者：
Ngai, John
影响因子：
2.5
作者：
Germanà, A;Montalbano, G;Vega, JA
通讯作者：
Vega, JA
影响因子：
3.5
作者：
Oka, Yuichiro;Korsching, Sigrun I.
通讯作者：
Korsching, Sigrun I.