Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma.
Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma.
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DOI：
10.3324/haematol.13071
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发表时间：
2008-09
期刊：
影响因子：
10.1
通讯作者：
Rosenwald, Andreas
中科院分区：
文献类型：
--
作者：
Salaverria, Itziar;Zettl, Andreas;Bea, Silvia;Hartmann, Elena M.;Dave, Sandeep S.;Wright, George W.;Boerma, Evert-Jan;Kluin, Philip M.;Ott, German;Chan, Wing C.;Weisenburger, Dennis D.;Lopez-Guillermo, Armando;Gascoyne, Randy D.;Delabie, Jan;Rimsza, Lisa M.;Braziel, Rita M.;Jaffe, Elaine S.;Staudt, Louis M.;Mueller-Hermelink, Hans Konrad;Campo, Elias;Rosenwald, Andreas
伯基特淋巴瘤是一种侵袭性B细胞淋巴瘤，具有典型的形态学、免疫表型和分子生物学特征。基因表达谱分析提供了伯基特淋巴瘤的分子特征，但也证明了不符合当前世界卫生组织伯基特淋巴瘤诊断标准的侵袭性B细胞淋巴瘤的子集仍然显示出伯基特淋巴瘤的分子特征（“不一致伯基特淋巴瘤”）。鉴于伯基特淋巴瘤和弥漫性大B细胞淋巴瘤的不同治疗，我们研究了基因表达定义的伯基特淋巴瘤的分子差异。我们通过比较基因组杂交和基因表达谱分析研究了51例伯基特淋巴瘤患者的肿瘤，其中26例为经典伯基特淋巴瘤，17例为非典型伯基特淋巴瘤，8例为“差异性伯基特淋巴瘤”。经典和非典型伯基特淋巴瘤（不包括“差异性伯基特淋巴瘤”），在成人和儿童病例中，在潜在的基因组不平衡或基因表达方面没有差异，表明这些亚组是分子同质的。然而，“不一致伯基特淋巴瘤”与经典/非典型伯基特淋巴瘤和弥漫性大B细胞淋巴瘤在绝对改变数量上有显著差异。此外，这一类别还包括同时携带t（14;18）和t（8;14）易位的淋巴瘤，其临床特征为成人患者的表现和侵袭性病程。儿童和成人伯基特淋巴瘤是分子同质性的，而“差异伯基特淋巴瘤”在潜在的遗传和临床特征与典型/非典型伯基特淋巴瘤不同。因此，“不一致伯基特淋巴瘤”可能形成侵袭性B细胞淋巴瘤的一个独特的遗传亚群，对多药化疗反应较差。
Burkitt’s lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt’s lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt’s lymphoma nonetheless show a molecular signature of Burkitt’s lymphoma (‘discrepant Burkitt’s lymphoma’). Given the different treatment of Burkitt’s lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt’s lymphoma. We studied tumors from 51 Burkitt’s lymphoma patients, comprising 26 with classic Burkitt’s lymphoma, 17 with atypical Burkitt’s lymphoma and 8 with ‘discrepant Burkitt’s lymphoma’, by comparative genomic hybridization and gene expression profiling. Classic and atypical Burkitt’s lymphoma (excluding ‘discrepant Burkitt’s lymphoma’), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. ‘Discrepant Burkitt’s lymphoma’, however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt’s lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course. Pediatric and adult Burkitt’s lymphoma are molecularly homogeneous, whereas ‘discrepant Burkitt’s lymphoma’ differ in underlying genetic and clinical features from typical/atypical Burkitt’s lymphoma. ‘Discrepant Burkitt’s lymphoma’ may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.
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影响因子：
7.5
作者：
Kanungo, A;Medeiros, LJ;Lin, P
通讯作者：
Lin, P
影响因子：
45.3
作者：
Macpherson, N;Lesack, D;Gascoyne, RD
通讯作者：
Gascoyne, RD
影响因子：
1.2
作者：
Lones, MA;Sanger, WG;Cairo, MS
通讯作者：
Cairo, MS
影响因子：
6.2
作者：
Onciu, Mihaela;Schlette, Ellen;Sandlund, John T.
通讯作者：
Sandlund, John T.
影响因子：
8
作者：
Wessendorf, S;Schwaenen, C;Bentz, M
通讯作者：
Bentz, M