Mesenchymal stromal cell therapy for the treatment of intestinal ischemia: Defining the optimal cell isolate for maximum therapeutic benefit.
Mesenchymal stromal cell therapy for the treatment of intestinal ischemia: Defining the optimal cell isolate for maximum therapeutic benefit.
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DOI：
10.1016/j.jcyt.2016.08.001
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发表时间：
2016-12
期刊：
影响因子：
4.5
通讯作者：
Markel, Troy A.
中科院分区：
文献类型：
--
作者：
Doster, Dominique L.;Jensen, Amanda R.;Khaneki, Sina;Markel, Troy A.
肠缺血是一种毁灭性的腹内急症，往往需要手术干预。死亡率可能很高，存活下来的患者往往有显著的长期发病率。在过去的十年中，传统医学疗法预防或治疗肠道缺血的实施很少，因此，新疗法的使用正变得越来越普遍。使用间充质间质细胞的细胞治疗是一种引起科学界关注的治疗方式。几个小组已经看到了细胞治疗的好处，但最佳细胞系尚未确定。本文的目的是：1)综述肠道缺血再灌注损伤的机制，2)确定细胞治疗该疾病的机制，3)比较不同的间充质干细胞组织来源，以最大限度地提高治疗肠道I/R疾病的潜在疗效。
Intestinal ischemia is a devastating intraabdominal emergency that often necessitates surgical intervention. Mortality rates can be high, and patients who survive often have significant long-term morbidity. The implementation of traditional medical therapies to prevent or treat intestinal ischemia have been sparse over the last decade, and therefore, the use of novel therapies are becoming more prevalent. Cellular therapy using mesenchymal stromal cells is one such treatment modality that is attracting noteworthy attention in the scientific community. Several groups have seen benefit with cellular therapy, but the optimal cell line has not been identified. The purpose of this review is to: 1) Review the mechanism of intestinal ischemia and reperfusion injury, 2) Identify the mechanisms of how cellular therapy may be therapeutic for this disease, and 3) Compare various MSC tissue sources to maximize potential therapeutic efficacy in the treatment of intestinal I/R diseases.
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