Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery.
Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery.
复制标题
用于靶向治疗递送的多功能和刺激响应性纳米载体。
DOI：
10.1080/17425247.2021.1828339
复制
发表时间：
2021-03
影响因子：
6.6
通讯作者：
Minko T
中科院分区：
文献类型：
--
作者：
Majumder J;Minko T
基于纳米载体的递送系统提供多种益处以克服传统药物剂型的局限性，例如保护药物、增强生物利用度、靶向递送至疾病部位等。纳米载体在靶向递送治疗剂至所需组织和细胞方面表现出巨大的成功，其具有改善的生物利用度、高载药量、增强的细胞内递送和更好的治疗效果。刺激响应性纳米载体的特定设计允许响应于外源性和内源性刺激而改变其结构和物理化学性质。这些纳米载体在某些生理条件或外部刺激下显示出治疗剂的位点特异性控制释放的前景。本文综述了近年来多功能、刺激敏感性纳米载体在靶向给药方面的研究进展。从单一功能到多功能的纳米载体的进展已经显示出巨大的潜力，靶向输送的治疗。我们认为，药物、核酸和其他物质的靶向递送的未来属于位点靶向的多功能和基于刺激的控释纳米粒。将纳米载体靶向疾病部位通过将更多的治疗剂特异性地递送至受影响的细胞并基本上限制对健康器官、组织和细胞的不良副作用来增强治疗的功效。
Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to the desired tissues and cells with improved bioavailability, high drug loading capacity, enhanced intracellular delivery, and better therapeutic effect. A specific design of stimuli-responsive nanocarriers allows for changing their structural and physicochemical properties in response to exogenous and endogenous stimuli. These nanocarriers show a promise in site specific controlled release of therapeutics under certain physiological conditions or external stimuli. This review highlights recent progresses on the multifunctional and stimuli-sensitive nanocarriers for targeted therapeutic drug delivery applications. The progress from single functional to multifunctional nanocarriers has shown tremendous potential for targeted delivery of therapeutics. On our opinion, the future of targeted delivery of drugs, nucleic acids, and other substances belongs to the site-targeted multifunctional and stimuli-based nanoparticles with controlled release. Targeting of nanocarriers to the disease site enhance the efficacy of the treatment by delivering more therapeutics specifically to the affected cells and substantially limiting adverse side effects upon healthy organs, tissues, and cells.
登录
查看更多内容
影响因子：
13.3
作者：
Chen, Alex M.;Zhang, Min;Wei, Dongguang;Stueber, Dirk;Taratula, Oleh;Minko, Tamara;He, Huixin
通讯作者：
He, Huixin
影响因子：
15
作者：
Agasti SS;Chompoosor A;You CC;Ghosh P;Kim CK;Rotello VM
通讯作者：
Rotello VM
影响因子：
5.4
作者：
Betigeri, Seema;Zhang, Min;Garbuzenko, Olga;Minko, Tamara
通讯作者：
Minko, Tamara
影响因子：
17.1
作者：
Chen, Alex M.;Taratula, Oleh;Wei, Dongguang;Yen, Hsin-I;Thomas, Thresia;Thomas, T. J.;Minko, Tamara;He, Huixin
通讯作者：
He, Huixin
影响因子：
5.2
作者：
Alfarouk KO;Muddathir AK;Shayoub ME
通讯作者：
Shayoub ME