Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis
Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis
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DNA修复基因的mRNA表达和遗传多态性与癌症风险的关联：生物信息学分析和荟萃分析
DOI：
10.7150/jca.30975
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发表时间：
2019-06
影响因子：
3.9
通讯作者：
Wei Minjie
中科院分区：
文献类型：
--
作者：
Wu Huizhe;Li Shanqiong;Hu Xiaoyun;Qin Wenyan;Wang Yilin;Sun Tong;Wu Zhikun;Wang Xiufang;Lu Senxu;Xu Dongping;Li Yalun;Guan Shu;Zhao Haishan;Yao Weifan;Liu Mingyan;Wei Minjie
本文通过系统的生物信息学和荟萃分析，对DNA修复基因与癌症发生之间的可能关系进行了研究。生物信息学分析证实，在19种癌症中观察到较低的XPA和XPC水平和较高的XPD，XPF和WRN水平，随后的结果表明，升高的XPA和XPC对总生存率有更好的影响，但较高的XPD，XPF和WRN对癌症预后的影响较差。纳入58项符合条件的研究的荟萃分析表明，携带XPA rs10817938，XPD rs238406的总体癌症风险增加，但总体癌症分析中的XPA rs2808668 SNP和消化系统中的XPF rs3136038显着降低癌症风险。此外，未研究XPC rs1870134、WRN rs1346044和rs1801195的相关性。这些结果表明，DNA修复基因与癌症发生相关，并有助于预后，关键SNP进一步参与影响癌症风险。
A systematical bioinformatics and meta-analysis were carried out to establish our understanding of possible relationships between DNA repair genes and the development of cancer. The bioinformatics analysis confirmed that lower XPA and XPC levels and higher XPD, XPF, and WRN levels were observed in 19 types of cancer, and subsequently results indicated that elevated XPA and XPC had a better impact on overall survival, however, higher XPD, XPF, and WRN showed worse influence on cancer prognosis. The meta-analysis included 58 eligible studies demonstrated that harboring XPA rs10817938, XPD rs238406 increased overall cancer risk, however, XPA rs2808668 SNP in overall cancer analysis and XPF rs3136038 in the digestive system remarkably reduced the cancer risk. Moreover, no correlation was investigated for XPC rs1870134, WRN rs1346044 and rs1801195. These suggest that the DNA repair gene was associated with carcinogenesis, and contribute to the prognosis, and the critical SNPs further involved in affecting cancer risk.
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影响因子：
3.8
作者：
Sugitani N;Sivley RM;Perry KE;Capra JA;Chazin WJ
通讯作者：
Chazin WJ
影响因子：
6.2
作者：
Han, Wonshik;Kim, Kyoung-Yeon;Kwack, KyuBum
通讯作者：
Kwack, KyuBum
影响因子：
2.8
作者：
Paszkowska-Szczur K;Scott RJ;Górski B;Cybulski C;Kurzawski G;Dymerska D;Gupta S;van de Wetering T;Masojć B;Kashyap A;Gapska P;Gromowski T;Kładny J;Lubiński J;Dębniak T
通讯作者：
Dębniak T
影响因子：
3.5
作者：
Mirecka, Aneta;Paszkowska-Szczur, Katarzyna;Debniak, Tadeusz
通讯作者：
Debniak, Tadeusz
DOI：
10.4238/2014.may.16.7
发表时间：
2014-05
期刊：
Genetics and molecular research : GMR
影响因子：
--
作者：
W. K. Zhou;L. Y. Huang;L. Hui;Z. W. Wang;B. Jin;X. Zhao;X. Z. Zhang;J. Wang;J. C. Wang;R. Wang
通讯作者：
W. K. Zhou;L. Y. Huang;L. Hui;Z. W. Wang;B. Jin;X. Zhao;X. Z. Zhang;J. Wang;J. C. Wang;R. Wang