Keratoconus detection using OCT corneal and epithelial thickness map parameters and patterns.
Keratoconus detection using OCT corneal and epithelial thickness map parameters and patterns.
复制标题
使用 OCT 角膜和上皮厚度图参数和模式进行圆锥角膜检测
DOI:
10.1097/j.jcrs.0000000000000498
复制
发表时间:
2021-06-01
影响因子:
2.8
通讯作者:
Li Y
中科院分区:
文献类型:
--
作者:
Yang Y;Pavlatos E;Chamberlain W;Huang D;Li Y
A 2-step decision tree method is provided to detect keratoconus with high accuracy using OCT corneal and epithelial thickness map parameters and patterns. Purpose: To detect keratoconus using optical coherence tomography (OCT) corneal map parameters and patterns. Setting: Casey Eye Institute, Oregon Health and Science University, Portland, Oregon. Design: Cross-sectional observational study. Methods: A spectral-domain OCT was used to acquire corneal and epithelial thickness maps in normal, manifest keratoconic, subclinical keratoconic, and forme fruste keratoconic (FFK) eyes. A 2-step decision tree was designed. An eye will be classified as keratoconus if both decision tree conditions are met. First, at least 1 of the 4 quantitative corneal thickness (minimum, minimum–maximum, and superonasal–inferotemporal) and epithelial thickness (standard deviation) map parameters exceed cutoff values. Second, presence of both concentric thinning pattern on the epithelial thickness map and coincident thinning patterns on corneal and epithelial thickness maps by visual inspection. Results: The study comprised 54 eyes from 29 normal participants, 91 manifest keratoconic eyes from 65 patients, 12 subclinical keratoconic eyes from 11 patients, and 19 FFK eyes from 19 patients. The decision tree correctly classified all normal eyes (100% specificity) and had good sensitivities for detecting manifest keratoconus (97.8%), subclinical keratoconus (100.0%), and FFK (73.7%). Conclusions: The 2-step decision tree provided a useful tool to detect keratoconus, including cases at early disease stages (subclinical keratoconus and FFK). OCT corneal and epithelial thickness map parameters and patterns can be used in conjunction with topography to improve keratoconus screening.
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DOI:
10.2147/opth.s147011
发表时间:
2017
期刊:
Clinical ophthalmology (Auckland, N.Z.)
影响因子:
--
作者:
Moshirfar M;Albarracin JC;Desautels JD;Birdsong OC;Linn SH;Hoopes PC Sr
通讯作者:
Hoopes PC Sr
影响因子:
0.4
作者:
Kanellopoulos AJ;Asimellis G
通讯作者:
Asimellis G
影响因子:
2.8
作者:
Gomes, Jose A. P.;Tan, Donald;Sangwan, Virender S.
通讯作者:
Sangwan, Virender S.
影响因子:
13.7
作者:
Li Y;Tan O;Brass R;Weiss JL;Huang D
通讯作者:
Huang D
影响因子:
1.7
作者:
Bohac, Maja;Koncarevic, Mateja;Patel, Sudi
通讯作者:
Patel, Sudi