Genetic and familial environmental effects on suicide--an adoption study of siblings.
Genetic and familial environmental effects on suicide--an adoption study of siblings.
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DOI：
10.1371/journal.pone.0077973
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hawton K
中科院分区：
文献类型：
--
作者：
Petersen L;Sørensen TI;Andersen PK;Mortensen PB;Hawton K
虽然有明确的证据表明家庭对自杀的影响，但这些影响的来源还不太确定。我们通过研究自杀死亡的被领养人的亲生兄弟姐妹和收养兄弟姐妹与幸存被领养人的兄弟姐妹的自杀发生率，调查了遗传和家庭环境因素。我们使用丹麦领养登记处和丹麦人口登记处对221名自杀死亡的被领养人的兄弟姐妹和1903名非自杀死亡的被领养人的兄弟姐妹进行了比较。丹麦领养登记处中的所有领养都是非家族性的，即养父母与被领养者在生物学上没有血缘关系。考虑到被领养人的自杀事件，同时考虑到精神障碍，对亲生兄弟姐妹和领养兄弟姐妹的自杀发生率进行了分析。60岁以前自杀身亡的被收养人的全同胞自杀风险显著高于未自杀的被收养者的全同胞(发生率比(IRR)=5.01；95%可信区间[CI]=1.28-19.6)。在调整了兄弟姐妹的精神住院史后，这一增长持续存在(IRR=4.19；95%CI=1.00-17.5)。遗传因素影响自杀风险，可能与精神障碍无关。这与向家庭提供咨询意见有关，包括可能防止自杀。
While there is clear evidence of familial influences on suicide, the origin of these is less certain. We have investigated genetic and familial environmental factors by studying the occurrence of suicide in biological and adoptive siblings of adoptees who died by suicide compared to siblings of surviving adoptees. We used the Danish Adoption Register and Danish population registers to compare 221 siblings of adoptees who died by suicide with the siblings of 1,903 adoptees who did not die by suicide. All adoptions in the Danish Adoption Register are non-familial, i.e. the adoptive parents are biologically unrelated to the adoptee. Analyses were conducted on incidence rates of suicide in biological and adoptive siblings given occurrence of suicide in the adoptees while also taking into account psychiatric disorders. The risk of suicide in full siblings of adoptees who died by suicide before age 60 years was significantly higher than in full siblings of adoptees who had not died by suicide (incidence rate ratios (IRR) = 5.01; 95% confidence interval [CI] = 1.28 - 19.6). This increase persisted after adjustment for history of psychiatric admission of siblings (IRR = 4.19; 95% CI = 1.00 - 17.5). Genetic factors influence risk of suicide, probably independently of psychiatric disorder. This is relevant in provision of advice to families, including possible prevention of suicide.
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影响因子：
3.7
作者：
Petersen L;Sørensen TI;Mortensen EL;Andersen PK
通讯作者：
Andersen PK
影响因子：
3.7
作者：
Petersen, Liselotte;Andersen, Per Kragh;Sorensen, Thorkild I. A.
通讯作者：
Sorensen, Thorkild I. A.
DOI：
10.1002/ajmg.c.30042
发表时间：
2005-02-15
影响因子：
3.1
作者：
Brent, DA;Mann, JJ
通讯作者：
Mann, JJ
影响因子：
168.9
作者：
GOLDACRE, M;SEAGROATT, V;HAWTON, K
通讯作者：
HAWTON, K
影响因子：
2.1
作者：
Petersen, L;Andersen, PK;Sorensen, TIA
通讯作者：
Sorensen, TIA