Excess mortality rate during adulthood among Danish adoptees.
Excess mortality rate during adulthood among Danish adoptees.
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DOI：
10.1371/journal.pone.0014365
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发表时间：
2010-12-16
期刊：
影响因子：
3.7
通讯作者：
Andersen PK
中科院分区：
文献类型：
--
作者：
Petersen L;Sørensen TI;Mortensen EL;Andersen PK
收养研究已经被用来解开来自共同家庭环境的基因对各种特征和疾病风险的影响。然而，导致收养和作为被收养者生活的两个因素可能会使研究在基因和环境相对于一般人群的影响方面产生偏差。目的是调查在丹麦进行这些研究的国内被收养者队列在全因死亡率和特定原因死亡率方面是否与一般人群相似。研究人员使用标准化死亡率（SMR）将1917年或之后出生于丹麦并于1924年至1947年被收养的13，111名被收养者与同一出生队列的所有丹麦人进行了比较。1970年活着的12，729名被收养者与所有丹麦人进行了类似的比较，使用SMR以及特定原因的SMR。被收养者65岁之前的全因死亡率估计为1.30（95% CI 1.26-1.35）。65岁以前的感染、血管性死亡、癌症、酒精相关死亡和自杀死亡率也明显过高。包括65岁以后死亡的分析通常显示死亡率略有上升，但全因死亡率、癌症、与酒精有关的死亡和自杀的上升幅度很大。与一般人口相比，残疾人的全因死亡率增加。所有主要的具体死亡原因都有贡献，与酒精有关的死亡率最高。
Adoption studies have been used to disentangle the influence of genes from shared familial environment on various traits and disease risks. However, both the factors leading to adoption and living as an adoptee may bias the studies with regard to the relative influence of genes and environment compared to the general population. The aim was to investigate whether the cohort of domestic adoptees used for these studies in Denmark is similar to the general population with respect to all-cause mortality and cause-specific mortality rates. 13,111 adoptees born in Denmark in 1917, or later, and adopted in 1924 to 1947 were compared to all Danes from the same birth cohorts using standardized mortality ratios (SMR). The 12,729 adoptees alive in 1970 were similarly compared to all Danes using SMR as well as cause-specific SMR. The excess in all-cause mortality before age 65 years in adoptees was estimated to be 1.30 (95% CI 1.26–1.35). Significant excess mortality before age 65 years was also observed for infections, vascular deaths, cancer, alcohol-related deaths and suicide. Analyses including deaths after age 65 generally showed slightly less excess in mortality, but the excess was significant for all-cause mortality, cancer, alcohol-related deaths and suicides. Adoptees have an increased all-cause mortality compared to the general population. All major specific causes of death contributed, and the highest excess is seen for alcohol-related deaths.
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影响因子：
2.1
作者：
Petersen, L;Andersen, PK;Sorensen, TIA
通讯作者：
Sorensen, TIA
影响因子：
6.7
作者：
BOHMAN, M;SIGVARDSSON, S
通讯作者：
SIGVARDSSON, S
影响因子：
7.7
作者：
Osler, Merete;Petersen, Liselotte;Sorensen, Thorkild I. A.
通讯作者：
Sorensen, Thorkild I. A.
影响因子：
158.5
作者：
SORENSEN, TIA;NIELSEN, GG;TEASDALE, TW
通讯作者：
TEASDALE, TW
影响因子：
5.4
作者：
Petersen, Liselotte;Andersen, Per Kragh;Sorensen, Thorkild I. A.
通讯作者：
Sorensen, Thorkild I. A.