Antimicrobial effectiveness of silver nanoparticles co-stabilized by the bioactive copolymer pluronic F68.
Antimicrobial effectiveness of silver nanoparticles co-stabilized by the bioactive copolymer pluronic F68.
复制标题
DOI：
10.1186/1477-3155-10-43
复制
发表时间：
2012-11-29
影响因子：
10.2
通讯作者：
Seckler MM
中科院分区：
文献类型：
--
作者：
dos Santos CA;Jozala AF;Pessoa A Jr;Seckler MM
银纳米粒子（AgNps）具有优良的抗菌性能，在生物医学工程领域引起了广泛的关注。因此，AgNps经常被考虑掺入用于皮肤病理学的医疗产品中以降低污染的风险。本研究旨在评估由pluronic™ F68稳定的AgNps与其他聚合物如聚乙烯醇（PVA）和聚乙烯吡咯烷酮（PVP）结合的抗微生物效果。采用最小抑菌浓度（MIC）法评价AgNps的抗菌活性。评估了与pluronic™ F68相关的不同聚合物针对革兰氏阴性细菌铜绿假单胞菌和大肠杆菌的作用谱。coli和革兰氏阳性菌S.奥瑞斯用PVP或PVA稳定并与pluronic™ F68共稳定的AgNps有效对抗大肠杆菌。大肠杆菌和铜绿假单胞菌微生物，MIC值低至原始AgNps分散体浓度的0.78%。对S.金黄色葡萄球菌的MIC值不低于25%。与未稳定化的AgNps相比，由不同聚合物系统稳定化的AgNps显示出对革兰氏阴性微生物的改善的抗微生物活性。与生物活性共聚物pluronic™ F68的共稳定进一步增强了对两种微生物的抗微生物有效性。对革兰氏阳性菌S.金黄色微生物未来的检测方法正在以可能的治疗应用为目标进行描述。
Silver nanoparticles (AgNps) have attracted much interest in biomedical engineering, since they have excellent antimicrobial properties. Therefore, AgNps have often been considered for incorporation into medical products for skin pathologies to reduce the risk of contamination. This study aims at evaluating the antimicrobial effectiveness of AgNps stabilized by pluronic™ F68 associated with other polymers such as polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP). AgNps antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) method. The action spectrum was evaluated for different polymers associated with pluronic™ F68 against the gram negative bacteria P. aeuroginosa and E. coli and the gram positive bacteria S. Aureus. AgNps stabilized with PVP or PVA and co-stabilized with pluronic™ F68 are effective against E. coli and P. aeruginosa microorganisms, with MIC values as low as 0.78% of the concentration of the original AgNps dispersion. The antimicrobial action against S. aureus is poor, with MIC values not lower than 25%. AgNps stabilized by different polymeric systems have shown improved antimicrobial activity against gram-negative microorganisms in comparison to unstabilized AgNps. Co-stabilization with the bioactive copolymer pluronic™ F68 has further enhanced the antimicrobial effectiveness against both microorganisms. A poor effectiveness has been found against the gram-positive S. aureus microorganism. Future assays are being delineated targeting possible therapeutic applications.
登录
查看更多内容
影响因子：
10.8
作者：
Croy, SR;Kwon, GS
通讯作者：
Kwon, GS
影响因子：
10.2
作者：
Irwin P;Martin J;Nguyen LH;He Y;Gehring A;Chen CY
通讯作者：
Chen CY
DOI：
10.1590/s1984-82502009000200008
发表时间：
2009-06-01
影响因子：
1.3
作者：
Mazzola, Priscila Gava;Jozala, Angela Faustino;Penna, Thereza Christina Vessoni
通讯作者：
Penna, Thereza Christina Vessoni
影响因子：
4.4
作者：
Pal, Sukdeb;Tak, Yu Kyung;Song, Joon Myong
通讯作者：
Song, Joon Myong
影响因子：
3.3
作者：
Panacek, Ales;Kvitek, Libor;Zboril, Radek
通讯作者：
Zboril, Radek