Host Factors That Control Mosquito-Borne Viral Infections in Humans and Their Vector.
Host Factors That Control Mosquito-Borne Viral Infections in Humans and Their Vector.
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DOI：
10.3390/v13050748
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发表时间：
2021-04-24
期刊：
影响因子：
--
通讯作者：
Goodman AG
中科院分区：
文献类型：
--
作者：
Trammell CE;Goodman AG
蚊子传播的病毒感染是地球仪上发病率和死亡率很高的原因，因为这些感染会导致严重的疾病，并且每年都在继续增加。这些病毒依赖于蚊子媒介作为传播到新的脊椎动物宿主（包括鸟类、牲畜和人类）的主要途径。由于蚊媒病毒在病媒和脊椎动物宿主之间传播时所经过的动态宿主环境，在病原体的生命周期过程中，有各种宿主因素控制对感染的反应。在这篇综述中，我们讨论了这些宿主因子，在感染过程中存在于载体或脊椎动物模型中，它们如何在宿主之间变化或保守，以及它们在未来疾病预防和治疗研究中的意义。
Mosquito-borne viral infections are responsible for a significant degree of morbidity and mortality across the globe due to the severe diseases these infections cause, and they continue to increase each year. These viruses are dependent on the mosquito vector as the primary means of transmission to new vertebrate hosts including avian, livestock, and human populations. Due to the dynamic host environments that mosquito-borne viruses pass through as they are transmitted between vector and vertebrate hosts, there are various host factors that control the response to infection over the course of the pathogen’s life cycle. In this review, we discuss these host factors that are present in either vector or vertebrate models during infection, how they vary or are conserved between hosts, and their implications in future research pertaining to disease prevention and treatment.
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