Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
复制标题
FTO 基因中的常见 SNP 与克罗地亚亚得里亚海东部海岸岛屿人口的肥胖相关人体测量特征相关。
DOI：
10.1371/journal.pone.0010375
复制
发表时间：
2010-04-28
期刊：
影响因子：
3.7
通讯作者：
Deka, Ranjan
中科院分区：
文献类型：
--
作者：
Zhang, Ge;Karns, Rebekah;Narancic, Nina Smolej;Sun, Guangyun;Cheng, Hong;Missoni, Sasa;Durakovic, Zijad;Rudan, Pavao;Chakraborty, Ranajit;Deka, Ranjan
多项研究提供了令人信服的证据，证明 FTO 基因变异与肥胖指标相关。该研究的目的是调查 FTO 变异是否与岛屿人群中广泛的肥胖相关人体测量特征相关。我们检查了来自克罗地亚亚得里亚海东部海岸岛屿种群的 843 个不相关个体的 29 个 FTO SNP 与一组全面的人体测量特征之间的遗传关联。这些特征包括 11 项人体测量数据（身高、体重、腰围、臀围、双髁上臂宽度、上臂周长以及二头肌、三头肌、肩胛下肌、上肌和腹部皮褶厚度）以及两项衍生指标（BMI 和 WHR）。通过单基因座评分测试，发现 15 个常见的 SNP 与体重、BMI、臀围和腰围等“身体脂肪”指标显着相关，P 值范围为 0.0004 至 0.01。在这些标记物与双髁上臂宽度和上臂周长之间也观察到类似但不太显着的关联。大多数这些重要的发现可以用“身体脂肪”的中介作用来解释。然而，上臂宽度和 rs16952517 之间的一个独特关联信号（P 值 = 0.00156）无法用这种中介效应来解释。此外，利用主成分分析和针对“身体肥胖”调整的条件关联测试，在上臂围与 rs11075986（P 值 = 0.00211）和 rs16945088（P 值 = 0.00203）之间发现了两个新的关联信号。目前的研究证实了 FTO 基因的常见变异与孤岛人群的“身体肥胖”指标之间的关联。我们还观察到FTO基因对无脂肪质量的多效性影响的证据，例如分别通过双髁上臂宽度和上臂周长评估的体格大小和肌肉质量，这些多效性效应可能受到与“身体肥胖”相关的变异不同的影响。
Multiple studies have provided compelling evidence that the FTO gene variants are associated with obesity measures. The objective of the study was to investigate whether FTO variants are associated with a broad range of obesity related anthropometric traits in an island population. We examined genetic association between 29 FTO SNPs and a comprehensive set of anthropometric traits in 843 unrelated individuals from an island population in the eastern Adriatic coast of Croatia. The traits include 11 anthropometrics (height, weight, waist circumference, hip circumference, bicondilar upper arm width, upper arm circumference, and biceps, triceps, subscapular, suprailiac and abdominal skin-fold thicknesses) and two derived measures (BMI and WHR). Using single locus score tests, 15 common SNPs were found to be significantly associated with “body fatness” measures such as weight, BMI, hip and waist circumferences with P-values ranging from 0.0004 to 0.01. Similar but less significant associations were also observed between these markers and bicondilar upper arm width and upper arm circumference. Most of these significant findings could be explained by a mediating effect of “body fatness”. However, one unique association signal between upper arm width and rs16952517 (P-value = 0.00156) could not be explained by this mediating effect. In addition, using a principle component analysis and conditional association tests adjusted for “body fatness”, two novel association signals were identified between upper arm circumference and rs11075986 (P-value = 0.00211) and rs16945088 (P-value = 0.00203). The current study confirmed the association of common variants of FTO gene with “body fatness” measures in an isolated island population. We also observed evidence of pleiotropic effects of FTO gene on fat-free mass, such as frame size and muscle mass assessed by bicondilar upper arm width and upper arm circumference respectively and these pleiotropic effects might be influenced by variants that are different from the ones associated with “body fatness”.
登录
查看更多内容
影响因子：
30.8
作者：
Chambers, John C.;Elliott, Paul;Kooner, Jaspal S.
通讯作者：
Kooner, Jaspal S.
影响因子：
2.1
作者：
Clayton, D;Chapman, J;Cooper, J
通讯作者：
Cooper, J
影响因子：
7.1
作者：
FRISANCHO, AR
通讯作者：
FRISANCHO, AR
影响因子：
56.9
作者：
Hill, JO;Peters, JC
通讯作者：
Peters, JC
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.