Curcumin/Fe-SiO2 nano composites with multi-synergistic effects for scar inhibition and hair follicle regeneration during burn wound healing
Curcumin/Fe-SiO2 nano composites with multi-synergistic effects for scar inhibition and hair follicle regeneration during burn wound healing
复制标题
姜黄素/Fe-SiO2纳米复合材料对烧伤创面抑制疤痕和毛囊再生具有多重协同作用
DOI：
10.1016/j.apmt.2021.101065
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发表时间：
2021-06
影响因子：
8.3
通讯作者：
Chang Jiang
中科院分区：
文献类型：
--
作者：
Zhang Zhaowenbin;Zhang Yu;Li Wenbo;Ma Lingling;Wang Endian;Xing Min;Zhou Yanling;Huan Zhiguang;Guo Feng;Chang Jiang
皮肤烧伤创面愈合过程中，瘢痕形成与毛囊再生密切相关。瘢痕部位过多的病理性成纤维细胞严重阻碍了毛囊干细胞向受损部位的迁移。因此，开发创面敷料抑制瘢痕形成，促进毛囊再生具有重要的临床意义。在本研究中，受SiO_32-−、Fe~(3+)和CuR的生物活性启发，我们设计了一种新型的纳米复合材料CuR-Fe-介孔二氧化硅纳米颗粒(CuR-Fe-SiO_2)。一方面，Fe~(3+)掺杂降低了介孔二氧化硅的稳定性，使其能够有效地释放生物活性的SiO_2−和Fe~(3+)。另一方面，在介孔二氧化硅孔表面释放的Fe3+离子与CuR发生络合作用，显著提高了CuR的负载量，与CuR或Fe相比，络合物具有更高的生物活性。释放的生物活性成分SiO_3~(2+)−、Fe~(3+)和Fe-CuR络合物具有抑制瘢痕增生和促进毛囊再生的协同作用。我们的结果表明，离子和类黄酮之间的协同效应可以用来提高生物材料的生物活性，设计生物活性离子和类黄酮的纳米复合材料可能是制备组织再生材料的有效途径。
The scar formation and hair follicle regeneration are closely related in the healing process of skin burn wounds. Excessive pathological fibroblasts at the scar site severely hinders the migration of hair follicle stem cells to the damaged site. Therefore, it is of great clinical significance to develop wound dressings to inhibit scar formation and promote hair follicle regeneration. In this study, inspired by the bioactivity of SiO32−, Fe3+and Cur, we designed a new type of nano composites, Cur-Fe-mesoporous silica nanoparticles (Cur-Fe-SiO2, MFSC). On the one hand, Fe3+doping reduced the stability of mesoporous silica, so that it can effectively release biologically active SiO32−and Fe3+. On the other hand, Fe3+ions released on the surface of the mesoporous silica pores chelated with the Cur in the solution and resulted in significantly improved loading of Cur and the chelates showed higher biological activity as compared to Cur or Fe alone. The released bioactive components such as SiO32−, Fe3+and Fe-Cur chelates showed synergistic activity in both inhibiting scar hyperplasia and promoting hair follicle regeneration. Our results suggest that the synergistic effects between ions and flavonoids can be used to increase the bioactivity of biomaterials, and design of nano composites with bioactive ions and flavonoids might be an effective approach to prepare materials for tissue regeneration.
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DOI：
10.1039/c5tb01440a
发表时间：
2015-11
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Jing Zhang;Haishan Shi;Jingqun Liu;Tao Yu-;Zuguang Shen;Jiandong Ye
通讯作者：
Jing Zhang;Haishan Shi;Jingqun Liu;Tao Yu-;Zuguang Shen;Jiandong Ye
毛囊真皮干细胞中β-连环蛋白的激活诱导异位毛发生长和皮肤纤维化
影响因子：
5.5
作者：
Yixin Tao;Qingchun Yang;Lei Wang;Jie Zhang;Xuming Zhu;Qianqian Sun;Yunbin Han;Qian Luo;Yushu Wang;Xizhi Guo;Ji Wu;Baojie Li;Xiao Yang;Lin He;Gang Ma
通讯作者：
Gang Ma
N-乙酰半胱氨酸负载氧化石墨烯-胶原蛋白杂化膜用于无疤痕伤口愈合
影响因子：
12.4
作者：
Li, Jialun;Zhou, Chuchao;Wang, Zhenxing
通讯作者：
Wang, Zhenxing
DOI：
10.1016/j.msec.2016.08.032
发表时间：
2016-12
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
M. Ranjbar-Mohammadi;S. Rabbani;S. Bahrami;M. Joghataei;F. Moayer
通讯作者：
M. Ranjbar-Mohammadi;S. Rabbani;S. Bahrami;M. Joghataei;F. Moayer
影响因子：
6.6
作者：
Kotcherlakota, Rajesh;Barui, Ayan Kumar;Gomez-Ruiz, Santiago
通讯作者：
Gomez-Ruiz, Santiago