Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster.
Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster.
复制标题
果蝇中有限异色因子的不同杂色重排之间的竞争。
作者：
V. Lloyd;D. Sinclair;T. Grigliatti
Position effect variegation (PEV) results from the juxtaposition of a euchromatic gene to heterochromatin. In its new position the gene is inactivated in some cells and not in others. This mosaic expression is consistent with variability in the spread of heterochromatin from cell to cell. As many components of heterochromatin are likely to be produced in limited amounts, the spread of heterochromatin into a normally euchromatic region should be accompanied by a concomitant loss or redistribution of the protein components from other heterochromatic regions. We have shown that this is the case by simultaneously monitoring variegation of a euchromatic and a heterochromatic gene associated with a single chromosome rearrangement. Secondly, if several heterochromatic regions of the genome share limited components of heterochromatin, then some variegating rearrangements should compete for these components. We have examined this hypothesis by testing files with combinations of two or more different variegating rearrangements. Of the nine combinations of pairs of variegating rearrangements we studied, seven showed nonreciprocal interactions. These results imply that many components of heterochromatin are both shared and present in limited amounts and that they can transfer between chromosomal sites. Consequently, even nonvariegation portions of the genome will be disrupted by re-allocation of heterochromatic proteins associated with PEV. These results have implications for models of PEV.
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影响因子：
3.3
作者：
Bishop,CP
通讯作者：
Bishop,CP
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影响因子：
3.3
作者：
Rushlow,CA;Bender,W;Chovnick,A
通讯作者：
Chovnick,A
影响因子：
4
作者：
KARPEN, GH
通讯作者：
KARPEN, GH
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影响因子：
3.3
作者：
Talbert,PB;LeCiel,CD;Henikoff,S
通讯作者：
Henikoff,S
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影响因子：
3.3
作者：
Locke,J;Kotarski,MA;Tartof,KD
通讯作者：
Tartof,KD