Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking.
Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking.
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DOI：
10.1038/npp.2009.49
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Staley JK
中科院分区：
文献类型：
--
作者：
Cosgrove KP;Krantzler E;Frohlich EB;Stiklus S;Pittman B;Tamagnan GD;Baldwin RM;Bois F;Seibyl JP;Krystal JH;O'Malley SS;Staley JK
吸烟与大量饮酒是高度共病的，但吸烟和饮酒对脑儿茶酚胺能突触标志物的相互作用尚不清楚。在这里，我们评估了单独饮酒与共病饮酒和吸烟对DA和5-HT转运体可用性的影响。14名重度饮酒吸烟者（n=6）和不吸烟者（n=8）以及14名年龄匹配的对照吸烟者（n=6）和不吸烟者（n=8）使用[123]β-CIT SPECT进行成像。饮酒吸烟者和非吸烟者在前一个月的饮酒量分别为134.3±100.3和196.5±139.9，并在急性戒断期间（例如，最后一次饮酒后5天内）进行成像。与对照组相比，饮酒者纹状体DA转运体利用率显著高于对照组（16%，P=0.04）。与对照组相比，饮酒者脑干（25%，P=0.001）和间脑（8%，P=0.01）的5-羟色胺转运体可用性也显著高于对照组。这种升高仅限于饮酒的非吸烟者，纹状体中DA转运体的可用性较高（26%，P=0.006），间脑和脑干中5-HT转运体的可用性较高（26%，P=0.04）和脑干中5-HT转运体的可用性较高（42%，P<.0002）。饮酒者和非吸烟者的间脑（r=0.60， P=0.023）和脑干（r=0.54， P=0.047）的5-羟色胺转运体利用率与最后一次饮酒的天数呈显著正相关，但与吸烟者无关。在戒酒的第一周，饮酒非吸烟者的DA和5-HT转运体可用性较高，而饮酒吸烟者则没有。在急性酒精戒断期间，吸烟似乎抑制了DA和5-HT转运体的神经适应性变化。
Tobacco smoking is highly comorbid with heavy alcohol drinking, yet the interactions of tobacco smoking and alcohol drinking on brain catecholaminergic synaptic markers is unexplored. Here we evaluate the effects of alcohol drinking alone from comorbid alcohol drinking and tobacco smoking on DA and 5-HT transporter availability. Fourteen heavy alcohol drinking smokers (n=6) and nonsmokers (n=8) and 14 age-matched control smokers (n=6) and nonsmokers (n=8) were imaged with [123]β-CIT SPECT. Alcohol drinking smokers and nonsmokers consumed 134.3±100.3 and 196.5±139.9 drinks, respectively over the previous month and were imaged during acute withdrawal, e.g., within 5 days of their last drink. Striatal DA transporter availability was significantly higher (16%, P=0.04) in alcohol drinkers compared to controls. 5-HT transporter availability was also significantly higher in alcohol drinkers versus controls in the brainstem (25%, P=0.001) and the diencephalon (8%, P=0.01). This elevation was restricted to alcohol drinking nonsmokers with higher DA transporter availability in the striatum (26%, P=0.006), and higher 5-HT transporter availability in the diencephalon (26%, P=0.04) and brainstem (42%, P<.0002). There was a significant positive correlation between days since last drink and 5-HT transporter availability in the diencephalon (r=0.60, P=0.023) and brainstem (r=0.54, P=0.047), in the total group of alcohol drinkers and in the nonsmokers, but not the smokers. During the first week of abstinence, DA and 5-HT transporter availability is higher in alcohol drinking nonsmokers but not in alcohol drinking smokers. Smoking appears to suppress neuroadaptive changes in DA and 5-HT transporters during acute withdrawal from alcohol.
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影响因子：
2.9
作者：
BACKSTROM, I;BERGSTROM, M;MARCUSSON, J
通讯作者：
MARCUSSON, J
DOI：
10.1111/j.1530-0277.2006.00261.x
发表时间：
2007-01-01
影响因子：
3.2
作者：
Brown, Amira K.;George, David T.;Innis, Robert B.
通讯作者：
Innis, Robert B.
影响因子：
11
作者：
Laine, TPJ;Ahonen, A;Hillbom, M
通讯作者：
Hillbom, M
影响因子：
--
作者：
Grant, BF;Hasin, DS;Dawson, DA
通讯作者：
Dawson, DA
影响因子：
10.6
作者：
LARUELLE, M;VANISBERG, MA;MALOTEAUX, JM
通讯作者：
MALOTEAUX, JM