Distinguishing externally from saccade-induced motion in visual cortex.

Distinguishing externally from saccade-induced motion in visual cortex.
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DOI:
10.1038/s41586-022-05196-w
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发表时间:
2022-10
期刊:
影响因子:
64.8
通讯作者:
Scanziani, Massimo
Scanziani, Massimo
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Miura, Satoru K.;Scanziani, Massimo

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区分由环境变化引起的感觉刺激和由动物自身行为引起的感觉刺激是感觉处理的一个标志。眼跳是一种快速的眼球运动,会使视网膜上的图像发生变化。视觉系统如何区分由眼跳引起的图像运动和环境中的实际运动尚不完全清楚。在这里,我们发现在小鼠初级视觉皮质(V1),这两种类型的运动引起不同的活动模式。这是因为,在眼跳过程中,V1将视觉输入与来自丘脑枕核的强烈非视觉输入结合在一起。非视觉输入触发特定于眼跳方向的反应,视觉输入触发特定于视网膜上刺激移动方向的反应,然而这两种反应的首选方向是不相关的。因此,枕骨输入确保了V1对外部和自身产生的运动的不同反应。外部感觉信息与身体运动信息的整合可能是感觉皮质区分自身产生的刺激和外部刺激的一般机制。初级视皮层中不同的活动模式将环境中的运动与眼睛运动引起的运动区分开来。
Distinguishing sensory stimuli caused by changes in the environment from those caused by an animal’s own actions is a hallmark of sensory processing. Saccades are rapid eye movements that shift the image on the retina. How visual systems differentiate motion of the image induced by saccades from actual motion in the environment is not fully understood. Here we discovered that in mouse primary visual cortex (V1) the two types of motion evoke distinct activity patterns. This is because, during saccades, V1 combines the visual input with a strong non-visual input arriving from the thalamic pulvinar nucleus. The non-visual input triggers responses that are specific to the direction of the saccade and the visual input triggers responses that are specific to the direction of the shift of the stimulus on the retina, yet the preferred directions of these two responses are uncorrelated. Thus, the pulvinar input ensures differential V1 responses to external and self-generated motion. Integration of external sensory information with information about body movement may be a general mechanism for sensory cortices to distinguish between self-generated and external stimuli. Distinct activity patterns in the primary visual cortex distinguish movement in the environment from motion caused by eye movements.
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影响因子: 64.8
作者:
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