Evolution of resistance to quorum-sensing inhibitors.
Evolution of resistance to quorum-sensing inhibitors.
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DOI：
10.1007/s00248-013-0316-y
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发表时间：
2014-07
影响因子：
3.6
通讯作者：
Kumar, Prasun
中科院分区：
文献类型：
--
作者：
Kalia, Vipin C.;Wood, Thomas K.;Kumar, Prasun
人类死亡和发病的主要原因是细菌感染。细菌已经对大多数抗生素产生了耐药性，主要是由于大规模和“不分青红皂白”的使用。需要开发新的机制来治疗细菌感染。细菌感染过程中致病性的表达是由称为群体感应（QS）的细胞密度依赖性现象介导的。一系列广泛的QS系统（QSS）可用于表达细菌病原体的毒力行为。每个QSS可能主要由几个主要信号沿着以微小数量产生的其他信号介导。靶向信号分子及其受体的努力已被证明有效地减轻了此类病原菌的毒性行为。据报道，这些QS抑制剂（QSI）可有效影响致病性而不影响细菌生长。然而，越来越多的证据表明，细菌可能对QSI产生耐药性。最大的问题是，QSI是否会遭遇与抗生素相同的命运？
The major cause of mortality and morbidity in human beings is bacterial infection. Bacteria have developed resistance to most of the antibiotics primarily due to large scale and “indiscriminate” usage. The need is to develop novel mechanisms to treat bacterial infections. The expression of pathogenicity during bacterial infections is mediated by a cell density dependent phenomenon known as quorum sensing (QS). A wide array of QS systems (QSS) is operative in expressing the virulent behavior of bacterial pathogens. Each QSS may be mediated largely by a few major signals along with others produced in minuscule quantities. Efforts to target signal molecules and their receptors have proved effective in alleviating the virulent behavior of such pathogenic bacteria. These QS inhibitors (QSIs) have been reported to be effective in influencing the pathogenicity without affecting bacterial growth. However, evidence is accumulating that bacteria may develop resistance to QSIs. The big question is whether QSIs will meet the same fate as antibiotics?
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影响因子：
3.6
作者：
BASSLER, BL;WRIGHT, M;SILVERMAN, MR
通讯作者：
SILVERMAN, MR
影响因子：
3
作者：
Annapoorani, Angusamy;Jabbar, Abdul Karim Kamil Abdul;Ravi, Arumugam Veera
通讯作者：
Ravi, Arumugam Veera
影响因子：
3.1
作者：
Bjarnsholt, Thomas;Givskov, Michael
通讯作者：
Givskov, Michael
影响因子：
11.6
作者：
Campbell, Alexandra H.;Harder, Tilmann;Steinberg, Peter D.
通讯作者：
Steinberg, Peter D.
影响因子：
3.2
作者：
Bleves, S;Soscia, C;Filloux, A
通讯作者：
Filloux, A