Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women.
Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women.
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DOI：
10.1186/1743-7075-9-99
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发表时间：
2012-11-09
影响因子：
4.5
通讯作者：
Mizutani T
中科院分区：
文献类型：
--
作者：
Akter S;Jesmin S;Islam M;Sultana SN;Okazaki O;Hiroe M;Moroi M;Mizutani T
在中国和西方，初潮年龄早与代谢综合征风险增加有关。然而，对南亚妇女初潮年龄和代谢综合征的影响知之甚少，包括来自低收入国家的妇女，那里的初潮年龄也在下降。本研究的目的是调查月经初潮年龄是否与孟加拉国妇女的代谢综合征呈负相关，孟加拉国妇女大多贫穷，获得和/或医疗保健设施有限。这项以社区为基础的横断面研究是在2009年和2010年对孟加拉国农村1423名年龄在15-75岁之间的妇女进行的。代谢综合征根据标准NCEP-ATP III标准定义。采用Logistic回归估计初潮年龄与代谢综合征之间的关系，并调整潜在的混杂变量，包括年龄、教育程度、婚姻状况、吸烟者、避孕药具使用情况和怀孕次数。与晚发（>13岁）相比，初潮早发（<12岁）与代谢综合征的患病率较高相关（比值比=1.55; 95%置信区间=1.05-2.30）。初潮年龄与高甘油三酯（P <0.01）和低高密度脂蛋白胆固醇（P = 0.01）的患病率呈负相关，但与高空腹血糖的患病率呈正相关（P =0.02）。然而，没有发现月经初潮年龄、高血压和腰围增加之间有明显的联系。月经初潮早发可能促进或触发代谢综合征的发生。因此，了解月经初潮开始时的年龄史可能是确定有患代谢综合征风险的妇女和那些可能从早期干预中获益最多的妇女的关键。
Early age at menarche is associated with increased risk of metabolic syndrome in both China and the West. However, little is known about the impact of age at menarche and metabolic syndrome in South Asian women, including those from low-income country, where age at menarche is also falling. The aim of the present study was to investigate whether age at menarche is inversely associated with metabolic syndrome in Bangladeshi women, who are mostly poor and have limited access to and or poor health care facilities. This community-based cross-sectional study was performed using 1423 women aged between 15–75 years from rural Bangladesh in 2009 and 2010. Metabolic syndrome was defined according to standard NCEP-ATP III criteria. Logistic regression was used to estimate the association between age at menarche and metabolic syndrome, with adjustment of potential confounding variables, including age, education, marital status, tobacco users, use of contraceptives and number of pregnancies. Early onset of menarche (<12 years) as compared to late onset (>13 years) was found to be associated with a higher prevalence of metabolic syndrome (odds ratio=1.55; 95 % confidence interval =1.05-2.30). Age at onset of menarche was also inversely associated with prevalence of high triglycerides (P for trend <0.01) and low high-density lipoprotein cholesterol (P for trend = 0.01), but positively associated with prevalence of high fasting blood glucose (P for trend =0.02). However, no significant association was found between age at menarche, high blood pressure and elevated waist circumference. Early onset of menarche might promote or trigger development of metabolic syndrome. Thus, knowledge of the history of age at onset of menarche may be critical in identifying women at risk of developing metabolic syndrome and those likely to benefit the most from early interventions.
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影响因子：
7.1
作者：
Biro, Frank M.;Wien, Michelle
通讯作者：
Wien, Michelle
影响因子：
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影响因子：
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作者：
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通讯作者：
Rand, WM
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通讯作者：
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