High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants.
High Rate of Cytomegalovirus Detection in Cholestatic Preterm Infants.
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DOI：
10.3389/fped.2021.754941
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发表时间：
2021
影响因子：
2.6
通讯作者：
Söderberg-Nauclér C
中科院分区：
文献类型：
--
作者：
Teng J;Elwin A;Omarsdottir S;Aquilano G;Vanpee M;Nemeth A;Rahbar A;Bohlin K;Fischler B;Söderberg-Nauclér C
目的：了解巨细胞病毒（CMV）感染在胆汁淤积症早产儿中的流行情况。研究设计：采用Taqman PCR技术对患有胆汁淤积症的早产儿（<37周孕龄）的全血、血浆和尿液中的血细胞进行巨细胞病毒DNA检测。如果任何样本检测呈阳性，则视为婴儿巨细胞病毒阳性。同时对其母亲进行巨细胞病毒血清检测。对照组的非胆汁淤积性早产儿及其母亲在相似的年龄接受了测试。结果：共纳入69例中位胎龄为26周5天的早产儿，其中胆汁淤积型45例，非胆汁淤积型24例。在胆汁淤积婴儿中，31/45（69%）为CMV阳性，3/24（13%）为非胆汁淤积婴儿（p < 0.001）。胆汁淤积症患儿与非胆汁淤积症患儿同样早产，但病情更为严重。在多变量logistic回归模型中，校正了坏死性小肠结肠炎、延长肠外营养和胎龄等危险因素后，CMV阳性仍与胆汁潴留显著相关。CMV阳性和阴性胆汁淤积婴儿的特征仅在坏死性小肠结肠炎和死亡率方面存在差异，CMV阳性婴儿的发生率为55% (17/31)，CMV阴性婴儿的发生率为21% (3/14)（p = 0.054）。8例胆汁淤积性cmv阳性婴儿死亡（26%），而cmv阴性婴儿无死亡（p = 0.044）。结论：CMV DNA在三分之二的胆汁淤积早产儿中检测到，远高于非胆汁淤积对照组。同时检测巨细胞病毒DNA的胆汁淤积可能与死亡率增加有关。
Objectives: To evaluate the prevalence of cytomegalovirus (CMV) infection in preterm infants with cholestasis. Study design: Preterm infants (<37 weeks gestational age) with cholestasis were tested for CMV DNA using Taqman PCR in blood cells from sedimented whole blood, plasma, and urine. Infants were regarded as positive for CMV if any sample was tested positive. Their mothers were tested for CMV serostatus simultaneously. A control group of non-cholestatic preterm infants, and their mothers, were tested at a similar age. Results: A total of 69 preterm infants with a median gestational age of 26 weeks and 5 days were included, 45 cholestatic and 24 non-cholestatic. Of the cholestatic infants, 31/45 (69%) were CMV positive vs. 3/24 (13%) of the non-cholestatic infants (p < 0.001). Cholestatic infants were equally preterm as the non-cholestatic ones, but were more severely ill. After adjusting for the risk factors necrotizing enterocolitis, prolonged parenteral nutrition, and gestational age, being CMV positive remained significantly associated with cholestasis in a multivariable logistic regression model. Characteristics of CMV-positive and -negative cholestatic infants showed differences only for necrotizing enterocolitis, occurring in 55% (17/31) of CMV positive vs. 21% (3/14) of CMV negative (p = 0.054), and mortality. Eight cholestatic CMV-positive infants died (26%) vs. none of the CMV-negative infants (p = 0.044). Conclusions: CMV DNA was detected in two out of three cholestatic preterm infants, by far more often than in the non-cholestatic control group. Cholestasis with simultaneous detection of CMV DNA may be associated with increased mortality.
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影响因子：
2.7
作者：
Choi R;Lee S;Lee SG;Lee EH
通讯作者：
Lee EH
DOI：
10.1136/fn.80.2.f130
发表时间：
1999-03-01
影响因子：
4.4
作者：
Fischler, B;Rodensjö, P;Lewensohn-Fuchs, I
通讯作者：
Lewensohn-Fuchs, I
影响因子：
26.1
作者：
Kelly MS;Benjamin DK;Puopolo KM;Laughon MM;Clark RH;Mukhopadhyay S;Benjamin DK Jr;Smith PB;Permar SR
通讯作者：
Permar SR
影响因子：
1.5
作者：
Meshram H;Velhal S;Padwal V;Sutar J;Kadam R;Pereira J;Bhonde G;Karandikar K;Bhor V;Patel V;Shetty NS;Shah I
通讯作者：
Shah I
影响因子：
11.8
作者：
Townsend, Claire L.;Forsgren, Marianne;Peckham, Catherine S.
通讯作者：
Peckham, Catherine S.