Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice.
Dietary α-mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice.
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DOI：
10.1002/mnfr.201300771
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发表时间：
2014-06
影响因子：
5.2
通讯作者：
Failla, Mark L.
中科院分区：
文献类型：
--
作者：
Gutierrez-Orozco, Fabiola;Thomas-Ahner, Jennifer M.;Berman-Booty, Lisa D.;Galley, Jeffrey D.;Chitchumroonchokchai, Chureeporn;Mace, Thomas;Suksamrarn, Sunit;Bailey, Michael T.;Clinton, Steven K.;Lesinski, Gregory B.;Failla, Mark L.
溃疡性结肠炎（UC）是一种慢性炎症性结肠疾病。α-山竹素（α-Mangostin，α-MG）是山竹果中含量最丰富的氧杂蒽酮，具有抗炎和抗菌活性。我们评估了膳食α-MG对小鼠实验性结肠炎和健康小鼠肠道微生物群的影响。通过施用葡聚糖硫酸钠（DSS）在C57 BL/6 J小鼠中诱导结肠炎。小鼠饲喂对照饲料或含α-MG（0.1%）的饲料。α-MG加重DSS诱导的结肠炎病理。与对照组相比，喂食α-MG饮食的小鼠具有更大的结肠炎症和损伤，以及更大的CD 3+和F4/80+细胞浸润和结肠髓过氧化物酶。α-MG喂养动物的血清粒细胞集落刺激因子、IL-6和血清淀粉样蛋白A水平也高于对照组。喂食α-MG但未喂食DSS的健康小鼠的结肠和盲肠微生物群转变为变形菌门丰度增加，厚壁菌门和拟杆菌门丰度减少，这与人类UC中发现的特征相似。α-MG在DSS诱导的结肠炎期间加重结肠病理学。这些作用可能与α-MG诱导肠道生态失调有关。我们的研究结果表明，UC患者使用含α-MG的补充剂可能会产生意外风险。
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α-Mangostin (α-MG), the most abundant xanthone in mangosteen fruit, exerts anti-inflammatory and antibacterial activities in vitro. We evaluated the impact of dietary α-MG on murine experimental colitis and on the gut microbiota of healthy mice. Colitis was induced in C57BL/6J mice by administration of dextran sulfate sodium (DSS). Mice were fed control diet or diet with α-MG (0.1%). α-MG exacerbated the pathology of DSS-induced colitis. Mice fed diet with α-MG had greater colonic inflammation and injury, as well as greater infiltration of CD3+ and F4/80+ cells, and colonic myeloperoxidase, than controls. Serum levels of granulocyte colony-stimulating factor, IL-6, and serum amyloid A were also greater in α-MG-fed animals than in controls. The colonic and cecal microbiota of healthy mice fed α-MG but no DSS shifted to an increased abundance of Proteobacteria and decreased abundance of Firmicutes and Bacteroidetes, a profile similar to that found in human UC. α-MG exacerbated colonic pathology during DSS-induced colitis. These effects may be associated with an induction of intestinal dysbiosis by α-MG. Our results suggest that the use of α-MG-containing supplements by patients with UC may have unintentional risk.
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影响因子：
3.7
作者：
Joo YE;Karrasch T;Mühlbauer M;Allard B;Narula A;Herfarth HH;Jobin C
通讯作者：
Jobin C
影响因子：
4.4
作者：
Christensen, HR;Frokiær, H;Pestka, JJ
通讯作者：
Pestka, JJ
影响因子：
9.4
作者：
Fite, Alemu;Macfarlane, Sandra;Macfarlane, George T.
通讯作者：
Macfarlane, George T.
影响因子：
64.8
作者：
Khor, Bernard;Gardet, Agnes;Xavier, Ramnik J.
通讯作者：
Xavier, Ramnik J.
影响因子：
6.1
作者：
Gutierrez-Orozco F;Chitchumroonchokchai C;Lesinski GB;Suksamrarn S;Failla ML
通讯作者：
Failla ML