DNA-assisted swarm control in a biomolecular motor system.
DNA-assisted swarm control in a biomolecular motor system.
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DOI：
10.1038/s41467-017-02778-5
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发表时间：
2018-01-31
影响因子：
16.6
通讯作者：
Kakugo A
中科院分区：
文献类型：
--
作者：
Keya JJ;Suzuki R;Kabir AMR;Inoue D;Asanuma H;Sada K;Hess H;Kuzuya A;Kakugo A
在自然界中，蜂群行为在可移动的有机体中反复进化，因为它赋予了各种有益的紧急特性。这些措施包括改进信息收集、保护免受捕食者攻击和资源利用。一些生物体，例如蝗虫，会在孤独和群居行为之间切换，以响应外部刺激。由生物分子马达和细胞骨架细丝组成的动态超分子系统的群体行为已经被证明，其中交联剂诱导大规模的组织。如果能够对蜂群行为进行编程和控制，这种超分子系统的能力可能会进一步扩展。在这里，我们证明了由表面附着的动蛋白马达推动的DNA功能化微管(MTS)的聚集可以由DNA信号编程和可逆调节。可以通过调整MT刚度来选择紧急群体行为，如平移和圆周运动。含有偶氮苯基团的光响应性DNA能够在单独或成群行为之间切换，以响应可见光或紫外光的刺激。自行式分子实体可以在宏观尺度上研究群体行为，但尚未实现相互作用的可编程性。在这里，作者展示了DNA信号对DNA功能化微管的可逆调节，并通过使用光响应DNA链在孤立和成群行为之间切换。
In nature, swarming behavior has evolved repeatedly among motile organisms because it confers a variety of beneficial emergent properties. These include improved information gathering, protection from predators, and resource utilization. Some organisms, e.g., locusts, switch between solitary and swarm behavior in response to external stimuli. Aspects of swarming behavior have been demonstrated for motile supramolecular systems composed of biomolecular motors and cytoskeletal filaments, where cross-linkers induce large scale organization. The capabilities of such supramolecular systems may be further extended if the swarming behavior can be programmed and controlled. Here, we demonstrate that the swarming of DNA-functionalized microtubules (MTs) propelled by surface-adhered kinesin motors can be programmed and reversibly regulated by DNA signals. Emergent swarm behavior, such as translational and circular motion, can be selected by tuning the MT stiffness. Photoresponsive DNA containing azobenzene groups enables switching between solitary and swarm behavior in response to stimulation with visible or ultraviolet light. Self-propelled molecular entities enable studying swarm behavior on a macroscopic scale but programmability of interactions has yet not been achieved. Here the authors show reversible regulation of DNA-functionalized microtubules by DNA signals and switching between solitary and swarm behaviour by employing photoresponsive DNA strands.
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DOI：
10.1126/science.1226734
发表时间：
2012-11-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Derr ND;Goodman BS;Jungmann R;Leschziner AE;Shih WM;Reck-Peterson SL
通讯作者：
Reck-Peterson SL
影响因子：
13.3
作者：
Dinu, Cerasela Zoica;Opitz, Joerg;Diez, Stefan
通讯作者：
Diez, Stefan
影响因子：
64.5
作者：
Case, RB;Pierce, DW;Vale, RD
通讯作者：
Vale, RD
影响因子：
6.1
作者：
Hiyama, Satoshi;Moritani, Yuki;Sutoh, Kazuo
通讯作者：
Sutoh, Kazuo
影响因子：
8.6
作者：
Kraikivski, Pavel;Lipowsky, Reinhard;Kierfeld, Jan
通讯作者：
Kierfeld, Jan