A thermal nociceptive patch in the S2 cortex of nonhuman primates: a combined functional magnetic resonance imaging and electrophysiology study.
A thermal nociceptive patch in the S2 cortex of nonhuman primates: a combined functional magnetic resonance imaging and electrophysiology study.
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DOI：
10.1097/j.pain.0000000000002247
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发表时间：
2021-11-01
期刊：
影响因子：
7.4
通讯作者：
Chen LM
中科院分区：
文献类型：
--
作者：
Ye X;Yang PF;Liu Q;Dillenburger BD;Friedman RM;Chen LM
人类功能磁共振成像（fMRI）和行为学研究已经确定了沿侧裂皮层区域在感知主观疼痛中的作用。然而，对于这些区域的神经元如何表征和处理疼痛信息的感觉方面，以及它们的电生理活动如何与功能磁共振成像信号相关，人们知之甚少。目前的研究旨在通过在轻度麻醉下的松鼠猴顶盖的同源区域进行fmri引导的微电极测绘和记录研究，部分解决这一关键的知识差距。在研究的每只动物（n= 8）中，我们在外侧沟周围的皮质区域检测到中尺度的热伤害感觉迷你网络。在该网络中，我们发现了一个约1.5× 1.5 mm 2大小的皮质斑块，其中仅包含与热功能磁共振成像激活位点对齐的热伤害性神经元。这些神经元仅对热（热和冷）伤害性刺激反应缓慢，在连续刺激后持续放电数秒，并表现出多指感受野和高自发放电率。与功能磁共振成像的反应类似，在伤害范围内温度的升高导致放电率的非线性增加。热痛觉神经元集群的发现为研究灵长类动物大脑S2亚区的热痛觉独特的功能组织提供了新的见解。通过功能磁共振成像（fMRI），它支持了一种模式偏好的热伤害性斑块的存在，该斑块在空间上是分离的，并与含有具有类似感受野的神经元的触觉斑块混合在一起，并且在灵长类动物的眼皮层中存在功能不同的迷你网络。在非人类灵长类动物的次级体感觉皮层中，热痛觉神经元被组织成功能连贯的模块，仅包含热敏痛觉神经元。痛觉性热刺激引起的血氧水平依赖的功能性MRI信号变化与热痛觉性神经元的反应高度对应。
Human functional magnetic resonance imaging (fMRI) and behavioral studies have established the roles of cortical areas along the Sylvian fissure in sensing subjective pain. Yet, little is known about how sensory aspects of painful information are represented and processed by neurons in these regions and how their electrophysiological activities are related to fMRI signals. The current study aims to partially address this critical knowledge gap by performing fMRI-guided microelectrode mapping and recording studies in the homologous region of the parietal operculum in squirrel monkeys under light anesthesia. In each animal studied (n= 8), we detected mesoscale mini-networks for heat nociception in cortical regions around the lateral sulcus. Within the network, we discovered a∼ 1.5× 1.5-mm 2-sized cortical patch that solely contained heat nociceptive neurons that aligned with the heat fMRI activation locus. These neurons responded slowly to thermal (heat and cold) nociceptive stimuli exclusively, continued firing for several seconds after the succession of stimulation, and exhibited multidigit receptive fields and high spontaneous firing rates. Similar to the fMRI responses, increasing temperatures in the nociceptive range led to a nonlinear increase in firing rates. The finding of a clustering of heat nociceptive neurons provides novel insights into the unique functional organization of thermal nociception in the S2 subregion of the primate brain. With fMRI, it supports the existence of a modality-preferred heat nociceptive patch that is spatially separated and intermingled with touch patches containing neurons with comparable receptive fields and the presence of functionally distinct mini-networks in primate opercular cortex.Thermal nociception neurons are organized as functionally coherent modules that contain solely heat-sensitive nociceptive neurons in the secondary somatosensory cortex in nonhuman primates. There are high correspondences between nociceptive heat stimulus-evoked blood oxygenation-level–dependent functional MRI signal changes and responses of heat nociceptive neurons.
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