Best frequencies and temporal delays are similar across the low-frequency regions of the guinea pig cochlea.

Best frequencies and temporal delays are similar across the low-frequency regions of the guinea pig cochlea.
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DOI:
10.1126/sciadv.abq2773
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发表时间:
2022-09-23
期刊:
影响因子:
13.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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耳蜗将不同频率的音调映射到不同的解剖位置。例如,微弱的5000赫兹音调在18毫米长的豚鼠耳蜗中大约8毫米处产生活跃的反应,但在其他地方几乎没有反应。这种位置代码遍布听觉通路,其中神经元具有由其与听觉器官中的感觉细胞的连接所确定的“最佳频率”。然而,在耳蜗区域编码低频声音的频率选择性还没有得到系统的研究。在这里,我们展示了低频听觉根据一个不涉及位置代码的独特原理工作。相反,声音诱发的反应和时间延迟在耳蜗的低频区域是相似的。这些发现打破了被认为已经证明了100年的理论,对理解脑干和皮层的信息处理以及优化听觉植入物中的刺激传递具有广泛的意义。位置编码和传统的行波是不存在的耳蜗的低频区域。
The cochlea maps tones with different frequencies to distinct anatomical locations. For instance, a faint 5000-hertz tone produces brisk responses at a place approximately 8 millimeters into the 18-millimeter-long guinea pig cochlea, but little response elsewhere. This place code pervades the auditory pathways, where neurons have “best frequencies” determined by their connections to the sensory cells in the hearing organ. However, frequency selectivity in cochlear regions encoding low-frequency sounds has not been systematically studied. Here, we show that low-frequency hearing works according to a unique principle that does not involve a place code. Instead, sound-evoked responses and temporal delays are similar across the low-frequency regions of the cochlea. These findings are a break from theories considered proven for 100 years and have broad implications for understanding information processing in the brainstem and cortex and for optimizing the stimulus delivery in auditory implants. Place coding and conventional traveling waves are absent from the low-frequency regions of the cochlea.
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