Use of transfer impedance measurements for clinical assessment of lung mechanics.
Use of transfer impedance measurements for clinical assessment of lung mechanics.
复制标题
使用传输阻抗测量进行肺力学的临床评估。
DOI：
10.1164/ajrccm.157.2.9508067
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Jackson,AC
中科院分区：
文献类型：
--
作者：
Lutchen,KR;Sullivan,A;Arbogast,FT;Celli,BR;Jackson,AC
使用强迫振荡技术测量呼吸传递阻抗（Ztr）几乎不需要患者的配合，并提供了无创方法获取反映肺力学的数据。此外，zr的模型分析提供了独立气道和组织特性的可靠估计，但只有在获得64 Hz的数据时。目前的研究评估了1-80 Hz的ztr在评估肺功能受损程度和类型方面的临床应用。对37人进行了肺量测定和ztrs测量：11名健康受试者和26名肺部疾病患者，包括慢性阻塞性肺疾病（COPD）、哮喘、肺癌和结节病。在整个患者组中，有12人也是吸烟者。我们首先建立了几个Ztrfeatures的正态范围和模型估计的机械性能。慢性阻塞性肺病组和吸烟者组的部分光谱与健康组有显著差异。关键的ztr频谱特征包括阻抗实部为零的频率Ro；和Re4，阻抗的实部在4hz。关键模型参数为气道阻力，Raw。我们发现Raw、Re4和Roto在疾病期间显著升高（p < 0.0005），在支气管扩张剂治疗后显著降低（p < 0.025）。此外，我们发现Ro、Raw和re4与FVC和rovs FEV1之间存在中等到强的相关性。使用支气管扩张剂后，Ro、Re4和Raw的变化与几个肺活量指标的变化相关。Rofeature之前没有被评估过，因为它通常高于32 Hz（在患病个体中远高于32 Hz），并且在以前的临床研究中没有包含。
Respiratory transfer impedance (Ztr) measured using the forced oscillation technique requires virtually no patient cooperation and provides a noninvasive approach for acquiring data reflective of lung mechanics. Also, model analysis of Ztrprovides reliable estimates of separate airway and tissue properties , but only if data out to 64 Hz are acquired. The current study evaluated the clinical utility of Ztrfrom 1–80 Hz for assessing the degree and type of impaired lung function. Spirometry and Ztrmeasurements were made on 37 individuals: 11 healthy subjects and 26 patients with lung disease including chronic obstructive pulmonary disease (COPD), asthma, lung cancer, and sarcoidosis. Over the entire patient group, 12 were also smokers. We first established normal ranges for several Ztrfeatures and model estimated mechanical properties. The COPD and smokers groups showed significant differences in portions of their Ztrspectra from that of the healthy group. Key Ztrspectral features included Ro, the frequency at which the real part of impedance is zero; and Re4, the real part of impedance at 4 Hz. The key model parameter was airway resistance, Raw. We found Raw, Re4, and Roto be significantly elevated during disease (p < 0.0005) and to significantly decrease with bronchodilator therapy (p < 0.025). Moreover, we found moderate to strong correlations between Ro, Raw, and Re4versus FVC and Roversus FEV1. After bronchodilator, changes in Ro, Re4, and Raw were correlated with changes in several spirometric indices. The Rofeature has not been previously evaluated since it is typically above 32 Hz (well above 32 Hz in diseased individuals) and not encompassed in previous clinical studies.
登录
查看更多内容
通过可逆性气道阻塞中的转移呼吸阻抗和胸廓气体量来分离气道和组织特性。
影响因子：
24.3
作者：
F. Marchal;N. Bouaziz;C. Baeyert;C. Gallina;C. Duvivier;R. Peslin
通讯作者：
R. Peslin
早期气道疾病中总呼吸阻力的频率依赖性。
DOI：
--
发表时间：
2015
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
Kjeldgaard Jm;Richard W. Hyde;Speers Dm;Reichert Ww
通讯作者：
Reichert Ww
用六元模型分析呼吸转移阻抗的最佳频率范围。
影响因子：
3.3
作者：
W. Tomalak;R. Peslin;C. Duvivier;C. Gallina
通讯作者：
C. Gallina
总呼吸阻力和电抗作为对组胺支气管激发反应的测量。
DOI：
--
发表时间：
1989
期刊：
American Review of Respiratory Disease
影响因子：
--
作者：
J. Noord;J. Clement;K. V. D. Woestijne;M. Demedts
通讯作者：
M. Demedts
从传输阻抗得出的呼吸机械特性的置信区间。
影响因子：
3.3
作者：
M. Rotger;R. Peslin;E. Oostveen;C. Gallina
通讯作者：
C. Gallina