Medial prefrontal cortex and the temporal control of action.
Medial prefrontal cortex and the temporal control of action.
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DOI:
10.1016/bs.irn.2020.11.004
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发表时间:
2021
影响因子:
--
通讯作者:
Narayanan NS
中科院分区:
文献类型:
--
作者:
Zhang Q;Weber MA;Narayanan NS
Across species, the medial prefrontal cortex guides actions in time. This process can be studied using behavioral paradigms such as simple reaction-time and interval-timing tasks. Temporal control of action can be influenced by prefrontal neurotransmitters such as dopamine and acetylcholine and is highly relevant to human diseases such as Parkinson’s disease, schizophrenia, and attention-deficit hyperactivity disorder (ADHD). We review evidence that across species, medial prefrontal lesions impair the temporal control of action. We then consider neurophysiological correlates in humans, primates, and rodents that might encode temporal processing and relate to cognitive-control mechanisms. These data have informed brain-stimulation studies in rodents and humans that can compensate for timing deficits. This line of work illuminates basic mechanisms of temporal control of action in the medial prefrontal cortex, which underlies a range of high-level cognitive processing and could contribute to new biomarkers and therapies for human brain diseases.
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影响因子:
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作者:
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影响因子:
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作者:
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DOI:
10.1016/b978-0-444-64196-0.00004-2
发表时间:
2019-01-01
期刊:
CINGULATE CORTEX
影响因子:
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通讯作者:
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