Repeated Chlamydia trachomatis genital infections in adolescent women.
Repeated Chlamydia trachomatis genital infections in adolescent women.
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DOI：
10.1086/648734
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Fortenberry JD
中科院分区：
文献类型：
--
作者：
Batteiger BE;Tu W;Ofner S;Van Der Pol B;Stothard DR;Orr DP;Katz BP;Fortenberry JD
重复C。沙眼感染在性活跃的年轻妇女中很常见。再感染和抗生素治疗失败的相对频率尚未确定。纳入纵向队列的青少年女性每3个月进行一次行为和性传播感染评估，包括C。沙眼、ompA基因分型、访谈和日记记录，以记录伴侣特异性性交和事件特异性避孕套使用。使用算法将重复感染分类为再感染或治疗失败。所有有治疗结果的感染均用于估计抗生素使用有效性。我们在210名参与者中观察到478例感染事件; 176名妇女未感染。发病率为34/100女性年。在这些感染者中，121例有≥1次重复感染，形成268个发作对; 183对具有完整数据，并使用算法进行分类。在重复感染中，84.2%是明确的、很可能的或可能的再感染，13.7%是很可能的或可能的治疗失败，2.2%持续没有记录的治疗。对于318例可评价感染，我们估计治疗有效性为92.2%。在这个高发病率队列中，大多数重复衣原体感染是再感染，但也发生了治疗失败。我们的研究结果对男性筛查和伴侣通知计划有影响，并建议需要改进抗生素治疗。
Repeated C. trachomatis infections are common among young sexually active women. The relative frequency of re-infection and antibiotic treatment failure is undefined. Adolescent women enrolled in a longitudinal cohort had behavioral and sexually transmitted infection assessment every 3 months, including amplification tests for C. trachomatis, ompA genotyping and interviews and diary entries to document partner-specific coitus and event-specific condom use. Repeated infections were classified as re-infection or treatment failure using an algorithm. All infections with treatment outcomes were used to estimate antibiotic use-effectiveness. We observed 478 infection episodes among 210 participants; 176 women remained uninfected. Incidence rate was 34 per 100-woman years. Of those infected, 121 had ≥1 repeat infections forming 268 episode pairs; 183 pairs had complete data and were classified with the algorithm. Of repeated infections, 84.2% were definite, probable or possible re-infections, 13.7% were probable or possible treatment failures and 2.2% persisted without documented treatment. For 318 evaluable infections, we estimated a 92.2% treatment use-effectiveness. Most repeat chlamydial infections in this high incidence cohort were re-infections, but treatment failures occurred as well. Our results have implications for male screening and partner notification programs and suggest the need for improved antibiotic therapies.
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影响因子：
9.4
作者：
Klint, Markus;Fuxelius, Hans-Henrik;Herrmann, Bjorn
通讯作者：
Herrmann, Bjorn
DOI：
10.1016/s0002-9378(97)80020-8
发表时间：
1997-01-01
影响因子：
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作者：
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5.1
作者：
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通讯作者：
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影响因子：
3.6
作者：
Burstein, GR;Zenilman, JM;Quinn, TC
通讯作者：
Quinn, TC