Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years.
Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6-7 years.
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DOI：
10.1289/ehp.1104315
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发表时间：
2012-06
影响因子：
10.4
通讯作者：
Rauh V
中科院分区：
文献类型：
--
作者：
Perera FP;Tang D;Wang S;Vishnevetsky J;Zhang B;Diaz D;Camann D;Rauh V
背景：多环芳烃（PAH）是一种广泛存在于城市大气中的污染物，主要来源于化石燃料燃烧和其他燃烧源。我们以前曾报道过，在哥伦比亚儿童环境健康中心（CCCEH）的纵向队列研究中，脐带血中广泛的燃烧相关DNA加合物与6-7岁儿童的注意力问题有关。目的：我们在同一队列中评估了行为问题和两种不同的产前检查方法（均针对PAH）之间的关系。方法：在纽约市（NYC）对非吸烟的非洲裔美国人和多米尼加妇女的儿童从子宫内到6-7年进行随访。通过对孕妇在怀孕期间进行个人空气监测以及通过测量母体和脐带血中苯并[a]芘（BaP）（一种代表性PAH）特异性DNA加合物来估计产前PAH暴露。在6-7岁时，使用儿童行为检查表（CBCL）（n = 253）评估儿童行为。使用广义线性模型来测试产前多环芳烃暴露与行为结果之间的关联。结果如下：在多变量分析中，产前PAH高暴露，无论是通过个人空气监测（大于中位数2.27 ng/m3）还是通过母体和脐带加合物（可检测或更高）表征，均与焦虑/抑郁和注意力问题症状呈正相关（p ≤ 0.05）。结论：这些结果提供了额外的证据表明，在纽约市空气中遇到的PAH环境水平会对儿童行为产生不利影响。
Background: Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban air pollutants from fossil fuel burning and other combustion sources. We previously reported that a broad spectrum of combustion-related DNA adducts in cord blood was associated with attention problems at 6–7 years of age in the Columbia Center for Children’s Environmental Health (CCCEH) longitudinal cohort study. Objectives: We evaluated the relationship between behavioral problems and two different measures of prenatal exposure—both specific to PAH—in the same cohort. Methods: Children of nonsmoking African-American and Dominican women in New York City (NYC) were followed from in utero to 6–7 years. Prenatal PAH exposure was estimated by personal air monitoring of the mothers during pregnancy as well as by the measurement of DNA adducts specific to benzo[a]pyrene (BaP), a representative PAH, in maternal and cord blood. At 6–7 years of age, child behavior was assessed using the Child Behavior Checklist (CBCL) (n = 253). Generalized linear models were used to test the association between prenatal PAH exposure and behavioral outcomes. Results: In multivariate analyses, high prenatal PAH exposure, whether characterized by personal air monitoring (greater than the median of 2.27 ng/m3) or maternal and cord adducts (detectable or higher), was positively associated with symptoms of Anxious/Depressed and Attention Problems (p ≤ 0.05). Conclusion: These results provide additional evidence that environmental levels of PAH encountered in NYC air can adversely affect child behavior.
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影响因子：
8.3
作者：
Axtell, CD;Cox, C;Clarkson, TW
通讯作者：
Clarkson, TW
影响因子：
3.3
作者：
Archibong, AE;Inyang, F;Nyanda, AM
通讯作者：
Nyanda, AM
影响因子：
10.4
作者：
Choi, Hyunok;Jedrychowski, Wieslaw;Spengler, John;Camann, David E;Whyatt, Robin M;Rauh, Virginia;Tsai, Wei-Yann;Perera, Frederica P
通讯作者：
Perera, Frederica P
影响因子：
4.5
作者：
BUI, QQ;TRAN, MB;WEST, WL
通讯作者：
WEST, WL
影响因子：
2.7
作者：
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通讯作者：
Peluso, Marco