Biofilm on ventriculo-peritoneal shunt tubing as a cause of treatment failure in coccidioidal meningitis.

Biofilm on ventriculo-peritoneal shunt tubing as a cause of treatment failure in coccidioidal meningitis.
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DOI:
10.3201/eid0804.010103
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发表时间:
2002-04
影响因子:
11.8
通讯作者:
Costerton JW
Costerton JW
中科院分区:
医学2区
文献类型:
--
作者:
Davis LE;Cook G;Costerton JW

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我们描述了一例复发性球孢子菌性脑膜炎,尽管患者服用了足够剂量的氟康唑,但脑室-腹腔分流管尖端的真菌生物膜可能导致粗球孢子菌持续4年。真菌生物膜应被视为治疗失败和真菌持续存在的原因,特别是在存在人工假体或留置导管时。
We describe a case of recurrent coccidioidal meningitis in which a fungal biofilm on the tip of ventriculo-peritoneal shunt tubing was likely responsible for a 4-year persistence of Coccidioides immitis, despite the patient’s taking an adequate dosage of fluconazole. Fungal biofilms should be considered as a cause for treatment failure and fungal persistence, especially when artificial prostheses or indwelling catheters are present.
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