Evolutionary robustness of killer meiotic drives.
Evolutionary robustness of killer meiotic drives.
复制标题
DOI：
10.1002/evl3.255
复制
发表时间：
2021-10
影响因子：
5
通讯作者：
Wolf JB
中科院分区：
文献类型：
--
作者：
Madgwick PG;Wolf JB
减数分裂驱动因素是一种自私的遗传因素，它干扰减数分裂过程以促进自身的传播。最常见的干扰机制是配子杀死，减数分裂驱动杀死不包含它的配子。据预测，一种致命的减数分裂驱动因素将在种群中迅速传播，代价是基因组其余部分的其他基因。减数分裂杀手的快速传播预计会被快速传播的抑制基因所追逐，而这种抑制基因会恢复到正常的减数分裂。矛盾的是，虽然这可能意味着减数分裂的驱动因素在进化上应该是短暂的，但已经发现了许多古老的杀手减数分裂驱动因素，它们已经持续了数百万年。为了理解可能解释这种进化稳健性的理论基础，我们探索了杀手减数分裂驱动的不同可能机制和不同可能的相关抑制机制。我们使用了一个框架，该框架考虑了减数分裂的不同阶段如何导致不同组合中不同基因类型的细胞之间的不同结构相互作用。在可能的相互作用中，我们发现有三种不同的基因驱动机制，它们为不同类型的抑制子的传播创造了不同的选择性条件。我们发现，在姐妹细胞之间(减数分裂I之后和减数分裂II之前)，如果杀手减数分裂驱动因素在进化上比在减数分裂过程中的任何其他时间点都更加稳健。我们识别的不同驱动机制做出了可测试的预测，这可以解释为什么一些致命的减数分裂驱动是暂时的，而另一些是古老的。
A meiotic driver is a selfish genetic element that interferes with the process of meiosis to promote its own transmission. The most common mechanism of interference is gamete killing, where the meiotic driver kills gametes that do not contain it. A killer meiotic driver is predicted to spread rapidly through a population at the expense of other genes in the rest of the genome. The rapid spread of a killer meiotic driver is expected to be chased by the rapid spread of a suppressor that returns fair meiosis. Paradoxically, while this might imply that meiotic drivers should be evolutionarily transient, numerous ancient killer meiotic drivers have been discovered that have persisted for millions of years. To understand the rationale that could potentially explain such evolutionary robustness, we explore different possible mechanisms of killer meiotic drive and the different possible associated mechanisms of suppression. We use a framework that considers how the different stages of meiosis result in different structured interactions among cells with different genotypes in various combinations. Across possible interactions, we show that there are three genotypically distinct drive mechanisms that create alternative selective conditions for the spread of different types of suppressors. We show that killer meiotic drivers are more evolutionarily robust if they operate among sister cells (after meiosis I and before meiosis II) than at any other point during meiosis. The different drive mechanisms we identify make testable predictions that could explain why some killer meiotic drivers are transient while others are ancient.
登录
查看更多内容
影响因子：
16.6
作者：
Svedberg J;Hosseini S;Chen J;Vogan AA;Mozgova I;Hennig L;Manitchotpisit P;Abusharekh A;Hammond TM;Lascoux M;Johannesson H
通讯作者：
Johannesson H
影响因子：
2
作者：
HAIG, D;GRAFEN, A
通讯作者：
GRAFEN, A
DOI：
10.1016/j.tig.2018.02.003
发表时间：
2018-06
期刊：
Trends in genetics : TIG
影响因子：
--
作者：
Bravo Núñez MA;Nuckolls NL;Zanders SE
通讯作者：
Zanders SE
影响因子：
2
作者：
HAIG, D
通讯作者：
HAIG, D
影响因子：
16.6
作者：
Scott, Thomas W.;West, Stuart A.
通讯作者：
West, Stuart A.