Serum concentrations of small dense low-density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis.
Serum concentrations of small dense low-density lipoprotein cholesterol and lipoprotein(a) are related to coronary arteriostenosis in Takayasu arteritis.
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DOI：
10.1002/jcla.23966
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发表时间：
2021-12
影响因子：
2.7
通讯作者：
Yuan H
中科院分区：
文献类型：
--
作者：
Chen S;Luan H;He J;Wang Y;Liu S;Li Y;Zeng X;Yuan H
血清小而密低密度脂蛋白胆固醇（sdLDL-C）和脂蛋白（a）[Lp（a）]水平与冠状动脉疾病有关，但其与大动脉炎（TA）冠状动脉狭窄的具体关系尚未确定。本研究探讨了TA患者血清sdLDL-C和Lp（a）水平与冠状动脉狭窄以及动脉狭窄程度的相关性。这项回顾性研究包括190名TA患者和154名健康受试者。TA患者根据冠状动脉狭窄程度分为三类：I组，狭窄> 50%; II组，狭窄1%-50%; III组，狭窄0%。通过Logistic回归确定TA患者冠状动脉狭窄的独立危险因素，然后进行受试者工作特征曲线分析以确定危险因素的特异性和敏感性，并计算Youden指数评分以确定临界点。大动脉炎患者血清sdLDL ‐ C和Lp（a）水平显著高于健康对照组（p <0.0001）。第I组的总胆固醇、甘油三酯、LDL-C、sdLDL-C和Lp（a）水平以及sdLDL-C/LDL-C比值显著高于第II组和第III组（p <0. 05）。血清sdLDL-C水平升高使冠状动脉狭窄的风险增加5倍（临界值，0.605 mmol/l）。血清Lp（a）水平升高使冠状动脉狭窄的风险增加3.9倍（临界值，0.045 g/l）。sdLDL-C/LDL-C比值升高使冠状动脉狭窄的风险增加2.1倍（临界值，0.258）。血清sdLDL ‐ C、Lp（a）水平及sdLDL ‐ C/LDL ‐ C比值可作为TA患者冠状动脉狭窄的诊断指标。各组间sdLDL ‐ C和Lp（a）血清浓度比较。
Serum small dense low‐density lipoprotein cholesterol (sdLDL‐C) and lipoprotein(a) [Lp(a)] levels are related to coronary disease, but their specific associations with coronary arteriostenosis in Takayasu arteritis (TA) have not been ascertained. This study explored the correlations between serum sdLDL‐C and Lp(a) levels and coronary arteriostenosis in TA patients as well as the degree of artery stenosis. This retrospective study included 190 TA patients and 154 healthy subjects. TA patients were divided into three categories based on the degree of coronary stenosis: Group I, stenosis >50%; Group II, stenosis 1%–50%; and Group III, stenosis 0%. Independent risk factors for coronary arteriostenosis in TA were identified by logistic regression, followed by receiver operating characteristic curve analysis to determine the specificity and sensitivity of risk factors and Youden's Index score calculation to determine the cutoff points. Takayasu arteritis patients had significantly higher serum levels of sdLDL‐C and Lp(a) than healthy controls (p < 0.0001). The total cholesterol, triglyceride, LDL‐C, sdLDL‐C, and Lp(a) levels and the sdLDL‐C/LDL‐C ratio in Group I were significantly higher than those in Groups II and III (p < 0.05). An elevated serum sdLDL‐C level elevated the risk of coronary arteriostenosis by 5‐fold (cutoff value, 0.605 mmol/l). An increased serum Lp(a) level increased the risk of coronary arteriostenosis by 3.9‐fold (cutoff value, 0.045 g/l). An elevated sdLDL‐C/LDL‐C ratio increased the risk of coronary arteriostenosis by 2.1‐fold (cutoff value, 0.258). Serum sdLDL‐C and Lp(a) levels and sdLDL‐C/LDL‐C ratio may be used as diagnostic factors for coronary arteriostenosis in TA patients. Comparison of serum concentrations of sdLDL‐C and Lp(a) among the different groups.
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影响因子：
1
作者：
Kuijer A;van Oosterhout MF;Kloppenburg GT;Morshuis WJ
通讯作者：
Morshuis WJ
影响因子：
2.7
作者：
Fernandez-Cidon, Barbara;Candas-Estebanez, Beatriz;Pinto-Sala, Xavier
通讯作者：
Pinto-Sala, Xavier
影响因子：
6
作者：
Endo, M;Tomizawa, Y;Kasanuki, H
通讯作者：
Kasanuki, H
影响因子：
3.4
作者：
Atta, Ajax M.;Silva, Joao Paulo C. G.;Sousa Atta, Maria Luiza B.
通讯作者：
Sousa Atta, Maria Luiza B.
影响因子：
37.8
作者：
Kathiresan, S;Otvos, JD;Robins, SJ
通讯作者：
Robins, SJ