Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes.
Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes.
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DOI：
10.1517/17425255.2012.714366
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发表时间：
2012-11
影响因子：
4.3
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Kumar S;Jin M;Ande A;Sinha N;Silverstein PS;Kumar A
Alcohol consumption, which is highly prevalent in HIV-infected individuals, poses serious concerns in terms of rate of acquisition of HIV-1 infection, HIV-1 replication, response to highly active antiretroviral therapy (HAART) and AIDS/neuroAIDS progression. However, little is known about the mechanistic pathways by which alcohol exerts these effects, especially with respect to HIV-1 replication and the patient’s response to HAART. In this review, the authors discuss the effects of alcohol consumption on HIV-1 pathogenesis and its effect on HAART. They also describe the role of cytochrome P450 2E1 (CYP2E1) in alcohol-mediated oxidative stress and toxicity, and the role of CYP3A4 in the metabolism of drugs used in HAART (i.e., protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI)). Based on the most recent findings the authors discuss the role of CYP2E1 in alcohol-mediated oxidative stress in monocytes/macrophages and astrocytes, as well as the role of CYP3A4 in alcohol–PI interactions leading to altered metabolism of PI in these cells. The authors propose that alcohol and PI/NNRTI interact synergistically in monocytes/macrophages and astrocytes through the CYP pathway leading to an increase in oxidative stress and a decrease in response to HAART. Ultimately, this exacerbates HIV-1 pathogenesis and neuroAIDS.
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影响因子：
3.8
作者：
Boffito, Marta;Winston, Alan;Gazzard, Brian
通讯作者：
Gazzard, Brian
影响因子：
6.2
作者：
Cabral, Guy A.
通讯作者：
Cabral, Guy A.
影响因子：
1.5
作者：
Baum, Marianna K.;Rafie, Carlin;Campa, Adriana
通讯作者：
Campa, Adriana
影响因子：
4.1
作者：
Cobos-Jimenez, Viviana;Booiman, Thijs;Kootstra, Neeltje A.
通讯作者：
Kootstra, Neeltje A.
DOI：
10.1111/j.1460-9568.2010.07355.x
发表时间：
2010-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Ferrari LF;Levine JD
通讯作者：
Levine JD