SARS-CoV-2 exposure in wild white-tailed deer (Odocoileus virginianus).

SARS-CoV-2 exposure in wild white-tailed deer (Odocoileus virginianus).
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DOI:
10.1073/pnas.2114828118
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发表时间:
2021-11-23
影响因子:
11.1
通讯作者:
Shriner SA
Shriner SA
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Chandler JC;Bevins SN;Ellis JW;Linder TJ;Tell RM;Jenkins-Moore M;Root JJ;Lenoch JB;Robbe-Austerman S;DeLiberto TJ;Gidlewski T;Kim Torchetti M;Shriner SA

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广泛的人类SARS-CoV-2感染加上人与野生动物的相互作用,造成了人与野生动物之间反向人畜共患病的可能性。我们针对白尾鹿(Odocoileus Virginianus)进行血清监测,因为有证据表明,这些鹿具有与SARS-CoV-2高亲和力的血管紧张素转换酶2受体,对感染具有敏感性,表现出持续的病毒脱落,可以传播到同种群,表现出社会行为,并且可以在城市中心附近大量分布。我们评估了来自美国四个州的624份流行前和流行延迟的野鹿血清样本,以检测SARS-CoV-2的暴露情况。自2021年以来,使用替代病毒中和试验在152个样本(40%)中检测到抗体。用SARS-CoV-2病毒中和试验测试的样本子集显示测试之间高度一致。这些数据表明,被评估的种群中的白尾鹿曾接触过SARS-CoV-2。
Widespread human SARS-CoV-2 infections combined with human–wildlife interactions create the potential for reverse zoonosis from humans to wildlife. We targeted white-tailed deer (Odocoileus virginianus) for serosurveillance based on evidence these deer have angiotensin-converting enzyme 2 receptors with high affinity for SARS-CoV-2, are permissive to infection, exhibit sustained viral shedding, can transmit to conspecifics, exhibit social behavior, and can be abundant near urban centers. We evaluated 624 prepandemic and postpandemic serum samples from wild deer from four US states for SARS-CoV-2 exposure. Antibodies were detected in 152 samples (40%) from 2021 using a surrogate virus neutralization test. A subset of samples tested with a SARS-CoV-2 virus neutralization test showed high concordance between tests. These data suggest white-tailed deer in the populations assessed have been exposed to SARS-CoV-2.
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