Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-π in laryngeal carcinoma.
Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-π in laryngeal carcinoma.
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葡萄糖转运蛋白-1、P-糖蛋白、多药耐药相关蛋白和谷胱甘肽S-转移酶-γ在喉癌中的表达及意义
DOI：
10.3892/ol.2014.2752
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发表时间：
2015-02
期刊：
影响因子：
2.9
通讯作者：
Yao HT
中科院分区：
文献类型：
--
作者：
Mao ZP;Zhao LJ;Zhou SH;Liu MQ;Tan WF;Yao HT
增加葡萄糖转运蛋白 1 (GLUT-1) 活性是增加细胞葡萄糖流入的最重要方法之一。我们之前证明，GLUT-1 表达增加是喉癌患者生存的独立预测因子。因此，GLUT-1可能成为喉癌的新治疗靶点。本研究采用免疫组织化学方法研究喉癌中GLUT-1、P-糖蛋白（P-gp）、多药耐药相关蛋白1（MRP1）和谷胱甘肽S-转移酶-π（GST-π）的表达。此外，还分析了 GLUT-1 和 P-gp、MRP1 和 GST-π 以及各种临床病理参数之间可能的相关性。本研究中，GLUT-1、P-gp、MRP1和GST-π阳性率分别为52.9%（18/34）、58.8%（20/34）、20.6%（7/34）和58.8%（20/34）的喉癌。喉癌标本中GLUT-1、P-gp、MRP1、GST-π的表达高于喉癌前病变（P<0.05）。 Pearson 相关分析显示 GLUT-1 和 P-gp (r=0.364; P=0.034)、GLUT-1 和 MRP1 (r=0.359; P=0.037) 以及 P-gp 和 GST-π (r=0.426; P=0.012) 之间存在相关性。发现 GLUT-1 表达与肿瘤淋巴结转移分类（P=0.02）和临床分期（P=0.037）显着相关。此外，P-gp被发现与临床分期显着相关（P=0.026）。单变量分析显示，MRP1 表达与生存率差显着相关（c2=5.16；P=0.023）。多变量分析显示，淋巴结转移（P=0.009）和MRP1过表达（P=0.023）是生存不良的显着预测因素。本研究探讨了GLUT-1、P-gp、MRP1和GST-π在喉癌中的表达情况以及这些蛋白之间的相关性。研究发现 P-gp 与临床分期显着相关，而 MRP1 过表达与生存率低显着相关。
Increasing glucose transporter-1 (GLUT-1) activity is one of the most important ways to increase the cellular influx of glucose. We previously demonstrated that increased GLUT-1 expression was an independent predictor of survival in patients with laryngeal carcinoma. Thus, GLUT-1 may present a novel therapeutic target in laryngeal carcinoma. In this study, the expression of GLUT-1, P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and glutathione S-transferase-π (GST-π) in laryngeal carcinomas was investigated by immunohistochemistry. Additionally, possible correlations between GLUT-1 and P-gp, MRP1 and GST-π and various clinicopathological parameters were analyzed. In this study, 52.9% (18/34), 58.8% (20/34), 20.6% (7/34) and 58.8% (20/34) of the laryngeal carcinomas were positive for GLUT-1, P-gp, MRP1 and GST-π, respectively. The expression of GLUT-1, P-gp, MRP1 and GST-π was higher in laryngeal carcinoma specimens when compared with laryngeal precancerous lesions (P<0.05). Pearson’s correlation analysis showed correlations between GLUT-1 and P-gp (r=0.364; P=0.034), GLUT-1 and MRP1 (r=0.359; P=0.037) and P-gp and GST-π (r=0.426; P=0.012). GLUT-1 expression was found to significantly correlate with tumor-node-metastasis classification (P=0.02) and clinical stage (P=0.037). Furthermore, P-gp was found to significantly correlate with clinical stage (P=0.026). Univariate analysis showed that MRP1 expression was significantly associated with poor survival (c2=5.16; P=0.023). Multivariate analysis revealed that lymph node metastasis (P=0.009) and MRP1 overexpression (P=0.023) were significant predictors of poor survival. In the present study, the expression of GLUT-1, P-gp, MRP1 and GST-π in laryngeal carcinomas was investigated, as well as the correlations between these proteins. P-gp was found to significantly correlate with clinical stage, while MRP1 overexpression was significantly associated with poor survival.
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