Dopamine's role in social modulation of infant isolation-induced vocalization: II. Maternally modulated infant separation responses are regulated by D1- and D2-family dopamine receptors.
Dopamine's role in social modulation of infant isolation-induced vocalization: II. Maternally modulated infant separation responses are regulated by D1- and D2-family dopamine receptors.
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DOI：
10.1002/dev.20355
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发表时间：
2009-03
影响因子：
2.2
通讯作者：
Shair, Harry N.
中科院分区：
文献类型：
--
作者：
Muller, Jeff M.;Moore, Holly;Myers, Michael M.;Shair, Harry N.
关键词：
哺乳动物婴儿对照顾者的行为对生存至关重要，并可能在建立社会纽带方面发挥作用。大多数哺乳动物婴儿在与世隔绝时会发声。当幼鼠在与成年雌性动物互动后被隔离时，发声的速度比在与小鼠互动后更高，这种现象被称为母体增强。我们之前曾报道，D2受体家族激动剂奎比罗在与小鼠接触后不改变发音率的剂量下扰乱了母体的增强作用。在这里，我们进一步研究多巴胺在母体增强中的作用，通过测试D1和D2受体家族配体单独和联合对母体增强的影响。我们测试了这些药物在仔鼠接触后发出隔离发声的效果，然后在另一次隔离之前，暴露在麻醉的水坝或仅能处理的“拾起”条件下的一段短暂的“团聚”时期。刺激D2受体阻断了与DAM重合后发声的增加。D2受体的D2激动剂效应远大于拾取条件下的D2激动剂效应，进一步证明D2受体对母体增强具有选择性调节作用。另一方面，在所有实验条件下，全身性应用D1激动剂SKF81297可以非特异性地减少孤立发声。最后，D_1和D_2受体的双重拮抗剂，α-氟苯硫醇，增加了孤立发声和干扰增强，但剂量也抑制了运动。我们认为D2受体家族的激活比D1受体家族的激活对母体增强的干扰具有更强的选择性。
Mammalian infant behavior directed toward caregivers is critical to survival and may play a role in establishing social bonds. Most mammalian infants vocalize when isolated. Rat pups vocalize at a higher rate when isolated following an interaction with an adult female than after an interaction with littermates, a phenomenon termed maternal potentiation. We previously reported that the D2 receptor family agonist quinpirole disrupts maternal potentiation at a dose that does not alter vocalization rate following contact with littermates. Here we further examine the role of dopamine in maternal potentiation by testing effects of both D1 and D2 receptor family ligands, alone and in combination, on maternal potentiation. We tested the drugs’ effects on isolation vocalization subsequent to littermate contact and then another isolation preceded by a brief “reunion” period of exposure either to the anesthetized dam or a handling-only “pickup” condition. D2 receptor stimulation blocked the increase in vocalizations following reunion with the dam. The D2 agonist effect in the dam-reunion condition was much larger than its small effect in the pickup condition, providing further evidence that D2 receptors exert a selective modulation of maternal potentiation. On the other hand, systemic administration of the D1 agonist SKF81297 reduced isolation vocalizations nonspecifically, across all the experimental conditions. Finally, the D1 and D2 receptor dual antagonist, alpha-flupenthixol, increased isolation vocalizations and disrupted potentiation, but at doses that also inhibited locomotion. We conclude that D2 receptor family activation has a more selective effect of disrupting maternal potentiation than D1 receptor family activation.
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影响因子：
2.2
作者：
HOFER, MA;BRUNELLI, SA;SHAIR, HN
通讯作者：
SHAIR, HN
影响因子：
1.9
作者：
Muller, Jeff M.;Moore, Holly;Shair, Harry N.
通讯作者：
Shair, Harry N.
DOI：
10.1037/h0077665
发表时间：
1980-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
HOFER, MA;SHAIR, H
通讯作者：
SHAIR, H
影响因子：
1.9
作者：
Dickinson, A;Smith, J;Mirenowicz, J
通讯作者：
Mirenowicz, J
影响因子：
5.3
作者：
Aragona, BJ;Liu, Y;Wang, ZX
通讯作者：
Wang, ZX