Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain.
Rates of β-amyloid deposition indicate widespread simultaneous accumulation throughout the brain.
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DOI：
10.1016/j.neurobiolaging.2022.03.005
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发表时间：
2022-07
影响因子：
4.2
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
LaPoint, Molly R.;Baker, Suzanne L.;Landau, Susan M.;Harrison, Theresa M.;Jagust, William J.
淀粉样斑块聚集是阿尔茨海默病 (AD) 的病理标志，发生在疾病早期。然而，人们对它在整个大脑中的进展知之甚少。使用匹兹堡化合物 B (PIB)-PET 成像，我们研究了认知正常老年人中区域淀粉样蛋白积累的进展情况。我们发现，所有检查区域在与淀粉样蛋白阴性老年人的平均基线 PIB-PET 信号相对应的估计起始时间后 24-28 年达到峰值积累率。我们还研究了载脂蛋白-E ɛ4 等位基因增加的遗传风险对淀粉样蛋白积累率的影响，以及区域淀粉样蛋白积累与区域 tau 病理学（AD 的另一个标志）之间的关系，通过 Flortaucipir-PET 测量。 ɛ4 等位基因的携带者在所有大脑区域都有更快的淀粉样蛋白积累。此外，在除颞叶之外的所有区域中，淀粉样蛋白积累速度加快与 tau 蛋白负荷增加相关。这些结果表明，淀粉样蛋白几乎同时在整个大脑中积累，并与较高的 AD 病理相关，并且 AD 的遗传风险与淀粉样蛋白积累的加快有关。
Amyloid plaque aggregation is a pathologic hallmark of Alzheimer’s disease (AD) that occurs early in the disease. However, little is known about its progression throughout the brain. Using Pittsburgh Compound B (PIB)-PET imaging, we investigated the progression of regional amyloid accumulation in cognitively normal older adults. We found that all examined regions reached their peak accumulation rates 24–28 years after an estimated initiation corresponding to the mean baseline PIB-PET signal in amyloid-negative older adults. We also investigated the effect of increased genetic risk conferred by the apolipoprotein-E ɛ4 allele on rates of amyloid accumulation, as well as the relationship between regional amyloid accumulation and regional tau pathology, another hallmark of AD, measured with Flortaucipir-PET. Carriers of the ɛ4 allele had faster amyloid accumulation in all brain regions. Furthermore, in all regions excluding the temporal lobe, faster amyloid accumulation was associated with greater tau burden. These results indicate that amyloid accumulates near-simultaneously throughout the brain and is associated with higher AD pathology, and that genetic risk of AD is associated with faster amyloid accumulation.
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影响因子：
9.9
作者：
Grothe MJ;Barthel H;Sepulcre J;Dyrba M;Sabri O;Teipel SJ;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
5.7
作者：
Lockhart SN;Schöll M;Baker SL;Ayakta N;Swinnerton KN;Bell RK;Mellinger TJ;Shah VD;O'Neil JP;Janabi M;Jagust WJ
通讯作者：
Jagust WJ
影响因子：
4.2
作者：
Yotter RA;Doshi J;Clark V;Sojkova J;Zhou Y;Wong DF;Ferrucci L;Resnick SM;Davatzikos C
通讯作者：
Davatzikos C
影响因子：
7.7
作者：
Adams, Jenna N.;Maass, Anne;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
4.8
作者：
Insel, Philip S.;Mormino, Elizabeth C.;Donohue, Michael C.
通讯作者：
Donohue, Michael C.