Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden.
Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden.
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DOI：
10.1016/j.neurobiolaging.2013.05.030
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发表时间：
2013-12
影响因子：
4.2
通讯作者：
Davatzikos C
中科院分区：
文献类型：
--
作者：
Yotter RA;Doshi J;Clark V;Sojkova J;Zhou Y;Wong DF;Ferrucci L;Resnick SM;Davatzikos C
淀粉样蛋白成像化合物的开发已经允许淀粉样蛋白沉积的体内成像。在这项研究中，我们使用来自巴尔的摩老龄化纵向研究的匹兹堡化合物蓝（11 C-PiB）PET数据来检查整个大脑中淀粉样蛋白沉积的空间模式。我们使用了一种新的方法，使我们能够近似的空间模式的时间进展淀粉样斑块沉积的横截面数据。我们的研究结果与尸检研究中已知的进展模式一致，即额叶和楔前叶区域在疾病进展早期受到影响，枕叶和感觉运动皮质在疾病进展后期受到影响-在这里，疾病进展意味着总淀粉样蛋白负荷从低到高。此外，我们根据记忆表现的纵向变化将参与者分为亚组，并证明了这些亚组之间淀粉样蛋白沉积的估计进展的显著不同的空间模式。我们的研究结果表明，淀粉样蛋白沉积的空间模式与认知能力有关，可能比反映总淀粉样蛋白负荷的生物标志物更具信息性，这是目前的做法。这一发现对我们理解认知能力下降/恢复力与淀粉样蛋白沉积之间的关系以及将淀粉样蛋白成像用作研究和临床应用中的生物标志物具有广泛的意义。
The development of amyloid imaging compounds has allowed in vivo imaging of amyloid deposition. In this study, we examine the spatial patterns of amyloid deposition throughout the brain using Pittsburgh Compound Blue (11C-PiB) PET data from the Baltimore Longitudinal Study of Aging. We used a new methodology that allows us to approximate spatial patterns of the temporal progression of amyloid plaque deposition from cross-sectional data. Our results are consistent with patterns of progression known from autopsy studies, with frontal and precuneus regions affected early and occipital and sensorimotor cortices affected later in disease progression – here, disease progression means lower-to-higher total amyloid burden. Furthermore, we divided participants into subgroups based on longitudinal change in memory performance and demonstrated significantly different spatial patterns of the estimated progression of amyloid deposition between these subgroups. Our results indicate that the spatial pattern of amyloid deposition is related to cognitive performance and may be more informative than a biomarker reflecting total amyloid burden, which is the current practice. This finding has broad implications for our understanding of the relationship between cognitive decline/resilience and amyloid deposition, as well as for the use of amyloid imaging as a biomarker in research and clinical applications.
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影响因子：
7
作者：
Braak, H;Braak, E
通讯作者：
Braak, E
影响因子：
14.5
作者：
Pike, Kerryn E.;Savage, Greg;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
4.2
作者：
Forsberg, Anton;Engler, Henry;Nordberg, Agneta
通讯作者：
Nordberg, Agneta