A taste of the Drosophila gustatory receptors.
A taste of the Drosophila gustatory receptors.
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DOI：
10.1016/j.conb.2009.07.001
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发表时间：
2009-08
影响因子：
5.7
通讯作者：
Montell, Craig
中科院分区：
文献类型：
--
作者：
Montell, Craig
像果蝇（Drosophila melanogaster）这样的昆虫，依靠接触化学感觉来探测营养丰富的食物，避免摄入有毒化学物质，并选择配偶和适宜产卵的区域存款。苍蝇通过分布在身体多个部位（包括喙、翼缘、腿和产卵器）上的味觉刚毛和钉来感受促味剂和非挥发性信息素。感受器容纳味觉受体神经元，其表达68种味觉受体（GR）家族的成员。与由一种或两种受体类型的二聚体组成的受体启动的哺乳动物化学感觉或果蝇嗅觉相反，功能性果蝇GR可能包括三个或更多个亚基。几种GR似乎在与接触化学感觉无关的多种细胞类型中表达，这提高了这些蛋白质可能具有超出促味剂和信息素检测的作用的可能性。
Insects such as the fruit fly, Drosophila melanogaster, rely on contact chemosensation to detect nutrient-rich foods, to avoid consuming toxic chemicals, and to select mates and hospitable zones to deposit eggs. Flies sense tastants and non-volatile pheromones through gustatory bristles and pegs distributed on multiple body parts including the proboscis, wing margins, legs and ovipositor. The sensilla house gustatory receptor neurons, which express members of the family of 68 gustatory receptors (GRs). In contrast to mammalian chemosensation or Drosophila olfaction, which are initiated by receptors composed of dimers of one or two receptor types, the functional Drosophila GRs may include three or more subunits. Several GRs appear to be expressed in multiple cell types that are not associated with contact chemosensation raising the possibility that these proteins may have roles that extend beyond the detection of tastants and pheromones.
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