Subarachnoid hemorrhage fails to produce vasculopathy or chronic blood flow changes in rats.
Subarachnoid hemorrhage fails to produce vasculopathy or chronic blood flow changes in rats.
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蛛网膜下腔出血不会在大鼠中产生血管病变或慢性血流变化。
DOI：
10.1161/01.str.19.7.878
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发表时间：
1988
期刊：
影响因子：
8.3
通讯作者：
Solomon,RA
中科院分区：
文献类型：
--
作者：
Swift,DM;Solomon,RA
通过[14C]丁醇指示剂分馏技术测量蛛网膜下腔出血大鼠、对照大鼠和蛛网膜下腔注射缓冲盐水大鼠（假出血）的脑血流量。蛛网膜下腔出血组和假出血组脑血流量在注射后3h均明显下降。然而，血流量在24小时内恢复到对照水平，蛛网膜下腔出血后14天的测量未能显示脑血流量的任何延迟性下降。对处死前72小时蛛网膜下腔出血大鼠的基底动脉进行电子显微镜研究，未能显示出任何与人类或高等动物模型中血管痉挛相关的形态学变化。我们的研究表明，大鼠蛛网膜下腔出血模型对研究人类脑动脉瘤破裂后蛛网膜下腔出血的适用性有限。然而，尽管大鼠不是这种临床状况的完美模型，但在该模型中已经证明了与在人类蛛网膜下腔出血中观察到的病理生理变化相似的一些病理生理变化，值得进一步研究。
Cerebral blood flow was measured by a [14C]butanol indicator fractionation technique in rats subjected to subarachnoid hemorrhage, in control rats, and in rats given injections of buffered saline into the subarachnoid space (sham hemorrhage). Cerebral blood flow was significantly decreased in both the subarachnoid hemorrhage and sham hemorrhage rats 3 hours after injection. However, blood flow returned to control levels by 24 hours, and measurement for 14 days after subarachnoid hemorrhage failed to show any delayed decrease in cerebral blood flow. Electron microscopic studies of basilar arteries from rats subjected to subarachnoid hemorrhage 72 hours before killing failed to show any of the morphologic changes that have been associated with vasospasm in humans or in higher animal models. Our studies indicate that the rat model of subarachnoid hemorrhage has limited applicability to the study of subarachnoid hemorrhage following ruptured cerebral aneurysms in humans. However, although rats are not a perfect model of this clinical condition, some pathophysiologic changes similar to those observed in human subarachnoid hemorrhage have been demonstrated in this model and deserve further investigation.
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作者：
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DOI：
10.1016/s0006-291x(88)80528-x
发表时间：
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影响因子：
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DOI：
--
发表时间：
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期刊：
影响因子：
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通讯作者：
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