Oxidants differentially regulate the heat shock response.

Oxidants differentially regulate the heat shock response.
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氧化剂对热休克反应有不同的调节作用。

DOI:
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发表时间:
1997
影响因子:
3.1
通讯作者:
Pope L. Moseley
Pope L. Moseley
中科院分区:
医学2区
文献类型:
--
作者:
E. Wallen;Garry R. Buettner;Pope L. Moseley

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Cells, animals, and humans respond to hyperthermia through the synthesis of a family of proteins termed heat shock proteins (HSPs). Because hyperthermic stress may also result in mitochondrial uncoupling and the generation of reactive oxygen species, we wondered whether oxidant stress was sufficient to increase cellular levels of HSP70. HSP70 was detected in cells heated or treated with menadione but not in those treated with hydrogen peroxide or xanthine/xanthine oxidase. We speculate that oxidant stress from menadione exposure is qualitatively different from exposure from hydrogen peroxide or xanthine/xanthine oxidase.
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